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The population dynamics of hemoglobins A, A2, F and S in the context of the hemoglobinopathies HbS and α-thalassemia in Kenyan infants
- Source :
- e186, e184
- Publication Year :
- 2018
- Publisher :
- Ferrata Storti Foundation (Haematologica), 2018.
-
Abstract
- Few studies have described the dynamics of haemoglobin production in African populations with a high prevalence of haemoglobinopathies. We have used the BioRad Variant ClassicTM HPLC method to document the production patterns of the common haemoglobin variants HbA, HbA2, HbF and HbS, stratified by a+thalassaemia genotype, among 15,301 infants recruited to a study on the Coast of Kenya. Notably, we confirm that HbA2 measurements determined using this instrument are unreliable in HbAS and HbSS subjects. Further, we showed that HbA2 exceeded 4.0%, a level consistent with the presence of a-thalassaemia, in 0.8% of infants of HbAA phenotype who participated in our study. a-thalassaemia, has not been widely reported in the East Africa region and, as such, this finding merits further study.
- Subjects :
- congenital, hereditary, and neonatal diseases and abnormalities
Pediatrics
medicine.medical_specialty
education.field_of_study
Kenya
Science & Technology
Anemia
Thalassemia
Immunology
Population
Context (language use)
Hematology
Biology
medicine.disease
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Genotype
medicine
East africa
Hemoglobin
education
Life Sciences & Biomedicine
1102 Cardiorespiratory Medicine and Haematology
030215 immunology
Subjects
Details
- ISSN :
- 15928721 and 03906078
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Haematologica
- Accession number :
- edsair.doi.dedup.....a1f87bee8e7bfca89310a1e10b0f8c1a
- Full Text :
- https://doi.org/10.3324/haematol.2018.199596