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Serum prolactin levels in women with excessive milk production. Normalization by transitory prolactin inhibition
- Source :
- Acta endocrinologica. 109(4)
- Publication Year :
- 1985
-
Abstract
- Serum prolactin levels and milk yield were studied in 27 puerperae with excessive milk production (polygalactia) and compared with 30 normally lactating puerperae. In order to normalize polygalactia, 14 of these women were treated with 2.5 mg bromocriptine per day for 3 days starting on post-partum day 5, 13 women received placebo. Milk flow in polygalactic women started significantly earlier than in puerperae with normal milk yield and developed mean milk volumes of 816 g per day on post-partum day 4. Serum prolactin levels did not differ from levels of puerperae with normal milk yield. There was no correlation between serum prolactin and milk yield. Bromocriptine treatment resulted in a sharp but reversible decline of serum prolactin levels followed by a significant reduction of milk production. Bromocriptine could not be detected in milk specimens, while serum levels showed significant amounts. In placebo treated women prolactin levels and milk yield remained unaffected. These data indicate that serum prolactin concentrations of puerperae with polygalactia are within the normal post-partum range. Short term prolactin suppression by bromocriptine can reduce milk yield, without complete ablactation.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Lactation Disorders
Placebo
Serum prolactin
fluids and secretions
Endocrinology
Milk yield
Pregnancy
Internal medicine
Medicine
Humans
Milk flow
Bromocriptine
Clinical Trials as Topic
business.industry
Postpartum Period
food and beverages
General Medicine
Galactorrhea
Milk production
Prolactin
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 00015598
- Volume :
- 109
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Acta endocrinologica
- Accession number :
- edsair.doi.dedup.....a220fd420260500b6e061105311db50e