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Daily exercise enhances coronary resistance vessel sensitivity to pharmacological activation
- Source :
- Journal of Applied Physiology. 66:421-428
- Publication Year :
- 1989
- Publisher :
- American Physiological Society, 1989.
-
Abstract
- The effect of daily exercise on the coronary resistance vessel sensitivity to intracoronary infusion of several pharmacological agents was assessed in 12 conscious adult mongrel dogs. alpha-Adrenergic receptor agonists (norepinephrine and phenylephrine) significantly decreased coronary blood flow velocity. beta 2-Adrenergic receptor agonists (isoproterenol and zinterol) and a metabolic vasodilator (adenosine) significantly increased coronary blood flow velocity. These responses occurred without altering factors that influence myocardial metabolism. Daily exercise significantly enhanced the coronary vascular sensitivity to each of the pharmacological agents. These results suggest that a nonspecific potentiation to pharmacological activation occurs after daily exercise. After left stellate ganglionectomy, intracoronary infusions of each pharmacological agent had similar effects on coronary blood flow velocity as presented for the intact dogs; however, daily exercise did not enhance the coronary vascular sensitivity to the pharmacological agents. These results demonstrate the need for an intact nervous system for the vascular adaptations associated with daily exercise.
- Subjects :
- Periodicity
medicine.medical_specialty
Adenosine
Physiology
Vasodilator Agents
medicine.medical_treatment
Vasodilation
Norepinephrine (medication)
chemistry.chemical_compound
Dogs
Physical Conditioning, Animal
Physiology (medical)
Internal medicine
Animals
Vasoconstrictor Agents
Medicine
Ganglionectomy
Zinterol
Phenylephrine
Dose-Response Relationship, Drug
business.industry
Blood flow
Adrenergic beta-Agonists
Coronary Vessels
medicine.anatomical_structure
chemistry
Vascular resistance
Cardiology
Vascular Resistance
business
Adrenergic alpha-Agonists
medicine.drug
Subjects
Details
- ISSN :
- 15221601 and 87507587
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Physiology
- Accession number :
- edsair.doi.dedup.....a23f47231578532cf7f332fc3bb900cf