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Inhibitory Effects of Sizofiran on Anticancer Agent‐ or X‐Ray‐induced Sister Chromatid Exchanges and Mitotic Block in Murine Bone Marrow Cells

Authors :
Zhi-bo Yang
Yoshinori Tsuchiya
Masuo Hosokawa
Tadashi Arika
Source :
Japanese Journal of Cancer Research : Gann
Publication Year :
1993
Publisher :
Blackwell Publishing Ltd, 1993.

Abstract

The inhibitory effects of a biological response modifier (BRM), sizofiran, on sister chromatid exchanges (SCEs) in the bone marrow cells of mice treated with various anticancer agents or irradiation were investigated. Sizofiran (10 mg/kg i.m.) inhibited SCEs induced by mitomycin C (2 mg/kg i.v.), adriamycin (20 mg/kg i.v.) and cyclophosphamide (20 mg/kg i.v.) by about 20%, respectively. Analysis of the SCEs in vivo after irradiation plus sizofiran indicated that SCE levels were significantly lower than those observed in mice exposed to irradiation without sizofiran. Moreover, the effects of sizofiran were dependent on the timing of administration. Our results indicated that sizofiran should be administered simultaneously or soon after irradiation in order to minimize damage. Sizofiran also markedly restored the bone marrow cell mitosis which had been suppressed by anticancer agents, and this action was closely correlated with the prevention of increase in SCEs. These results indicate that in addition to immunopotentiating activity, sizofiran may play a role in preventing chromosomal damage induced by cancer chemotherapy and radiotherapy.

Details

Language :
English
ISSN :
18764673 and 09105050
Volume :
84
Issue :
5
Database :
OpenAIRE
Journal :
Japanese Journal of Cancer Research : Gann
Accession number :
edsair.doi.dedup.....a24960515676793895a390e5303c9972