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Microbial Transformations of α-Santonin
- Source :
- Zeitschrift für Naturforschung C. 59:209-214
- Publication Year :
- 2004
- Publisher :
- Walter de Gruyter GmbH, 2004.
-
Abstract
- Fungal biotransformations of alpha-santonin (1) were conducted with Mucor plumbeus (ATCC 4740), Cunninghamella bainieri (ATCC 9244), Cunninghamella echinulata (ATCC 9245), Curvularia lunata (ATCC 12017) and Rhizopus stolonifer (ATCC 10404). Rhizopus stolonifer (ATCC 10404) metabolized compound 1 to afford 3,4-epoxy-alpha-santonin (2) and 4,5-dihydro-alpha-santonin (3) while Cunninghamella bainieri (ATCC 9244), Cunninghamella echinulata (ATCC 9245) and Mucor plumbeus (ATCC 4740) were capable of metabolizing compound 1 to give a reported metabolite, 1,2-dihydro-alpha-santonin (4). The structures of these transformed metabolites were established with the aid of extensive spectroscopic studies. These fungi regiospecifically reduced the carbon-carbon double bond in ring A of alpha-santonin.
- Subjects :
- Curvularia lunata
chemistry.chemical_classification
Mucor plumbeus
Double bond
Cunninghamella bainieri
biology
Stereochemistry
Metabolite
biology.organism_classification
General Biochemistry, Genetics and Molecular Biology
chemistry.chemical_compound
Species Specificity
chemistry
Mucor
Rhizopus stolonifer
Santonin
Biotransformation
Cunninghamella
Rhizopus
Cunninghamella echinulata
Subjects
Details
- ISSN :
- 18657125 and 09395075
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Zeitschrift für Naturforschung C
- Accession number :
- edsair.doi.dedup.....a24f34627b8d41d0214bb274ecebed79
- Full Text :
- https://doi.org/10.1515/znc-2004-3-415