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Epidermal growth factor receptor is a preferred target for treating Amyloid-β–induced memory loss
- Source :
- Proceedings of the National Academy of Sciences. 109:16743-16748
- Publication Year :
- 2012
- Publisher :
- Proceedings of the National Academy of Sciences, 2012.
-
Abstract
- Current understanding of amyloid-β (Aβ) metabolism and toxicity provides an extensive list of potential targets for developing drugs for treating Alzheimer’s disease. We took two independent approaches, including synaptic-plasticity–based analysis and behavioral screening of synthetic compounds, for identifying single compounds that are capable of rescuing the Aβ-induced memory loss in both transgenic fruit fly and transgenic mouse models. Two clinically available drugs and three synthetic compounds not only showed positive effects in behavioral tests but also antagonized the Aβ oligomers-induced activation of the epidermal growth factor receptor (EGFR). Such surprising converging outcomes from two parallel approaches lead us to conclude that EGFR is a preferred target for treating Aβ-induced memory loss.
- Subjects :
- Genetically modified mouse
Memory Disorders
Amyloid beta-Peptides
Multidisciplinary
COS cells
Transgene
Memantine
Biological Sciences
Biology
Pharmacology
ErbB Receptors
Gefitinib
Epidermal growth factor
Toxicity
medicine
biology.protein
Animals
Humans
Epidermal growth factor receptor
Protein Kinase Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....a2527c1a042e2d154de8adccf627d7d8