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Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study
- Source :
- Nutrients, Vol 10, Iss 5, p 586 (2018), Nutrients, Nutrients; Volume 10; Issue 5; Pages: 586
- Publication Year :
- 2018
-
Abstract
- There is a widely acknowledged association between insulin resistance and obesity/type 2 diabetes (T2DM), and insulin sensitizing treatments have proved effective in preventing diabetes and inducing weight loss. Obesity and T2DM are also associated with increased inflammation. Mangosteen is a tropical tree, whose fruits—known for their antioxidant properties—have been recently suggested having a possible further role in the treatment of obesity and T2DM. The objective of this pilot study has been to evaluate safety and efficacy of treatment with mangosteen extract on insulin resistance, weight management, and inflammatory status in obese female patients with insulin resistance. Twenty-two patients were randomized 1:1 to behavioral therapy alone or behavioral therapy and mangosteen and 20 completed the 26-week study. The mangosteen group reported a significant improvement in insulin sensitivity (homeostatic model assessment-insulin resistance, HOMA-IR −53.22% vs. −15.23%, p = 0.004), and no side effect attributable to treatment was reported. Given the positive preliminary results we report and the excellent safety profile, we suggest a possible supplementary role of mangosteen extracts in the treatment of obesity, insulin resistance, and inflammation.
- Subjects :
- 0301 basic medicine
Blood Glucose
Garcinia mangostana
inflammation
insulin resistance
metabolic syndrome
diabetes
xanthones
mangostin
phytotherapy
dietary supplements
medicine.medical_treatment
Health Behavior
Pilot Projects
Type 2 diabetes
Pharmacology
Antioxidants
chemistry.chemical_compound
0302 clinical medicine
Insulin
Prospective Studies
Nutrition and Dietetics
Anthropometry
Middle Aged
Body Composition
Female
lcsh:Nutrition. Foods and food supply
Adult
food.ingredient
Adolescent
030209 endocrinology & metabolism
lcsh:TX341-641
Article
03 medical and health sciences
Young Adult
food
Insulin resistance
Diabetes mellitus
medicine
Humans
Obesity
Mangostin
Life Style
Aged
030109 nutrition & dietetics
business.industry
Plant Extracts
medicine.disease
chemistry
Diabetes Mellitus, Type 2
Fruit
Metabolic syndrome
business
Biomarkers
Food Science
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nutrients, Vol 10, Iss 5, p 586 (2018), Nutrients, Nutrients; Volume 10; Issue 5; Pages: 586
- Accession number :
- edsair.doi.dedup.....a2613858f754d6c143af93e963f8d4f2