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High-Fat Diets Modify the Proteolytic Activities of Dipeptidyl-Peptidase IV and the Regulatory Enzymes of the Renin–Angiotensin System in Cardiovascular Tissues of Adult Wistar Rats
- Source :
- Biomedicines, Vol 9, Iss 1149, p 1149 (2021), Biomedicines, Volume 9, Issue 9, Digibug. Repositorio Institucional de la Universidad de Granada, instname
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- (1) Background: The replacement of diets high in saturated fat (SAFA) with monounsaturated fatty acids (MUFA) is associated with better cardiovascular function and is related to the modulation of the activity of the local renin–angiotensin system (RAS) and the collagenase activity of dipeptidyl peptidase IV (DPP-IV). The objective of the work was to verify the capacity of different types of dietary fat on the regulatory activities of RAS and DPP-IV. (2) Methods: Male Wistar rats were fed for 24 weeks with three different diets: the standard diet (S), the standard diet supplemented with virgin olive oil (20%) (VOO), or with butter (20%) plus cholesterol (0.1%) (Bch). The proteolytic activities were determined by fluorometric methods in the soluble (sol) and membrane-bound (mb) fractions of the left ventricle and atrium, aorta, and plasma samples. (3) Results: With the VOO diet, angiotensinase values were significantly lower than with the Bch diet in the aorta (GluAP and ArgAP (mb)), ventricle (ArgAP (mb)) and atrium (CysAP (sol)). Significant decreases in DPP-IV (mb) activity occurred with the Bch diet in the atrium and aorta. The VOO diet significantly reduced the activity of the cardiac damage marker LeuAP (mb) in the ventricle and aorta, except for LeuAP (sol) in the ventricle, which was reduced with the Bch diet. (4) Conclusions: The introduction into the diet of a source rich in MUFA would have a beneficial cardiovascular effect on RAS homeostasis and cardiovascular functional stability.<br />ACCIÓN 1 PAIUJA 2019 2020: BIO221.
- Subjects :
- medicine.medical_specialty
aminopeptidase activities
QH301-705.5
Saturated fat
Medicine (miscellaneous)
Aminopeptidase activity
General Biochemistry, Genetics and Molecular Biology
Dipeptidyl peptidase
Article
chemistry.chemical_compound
Internal medicine
medicine.artery
Renin–angiotensin system
Virgin olive oil
medicine
dipeptidyl peptidase IV
Biology (General)
Aorta
Atrium (architecture)
Chemistry
Cholesterol
angiotensinases
medicine.anatomical_structure
Endocrinology
High-fat diet
high-fat diet
virgin olive oil
Ventricle
Dipeptidyl peptidase IV
Angiotensinases
Homeostasis
Subjects
Details
- Language :
- English
- ISSN :
- 22279059
- Volume :
- 9
- Issue :
- 1149
- Database :
- OpenAIRE
- Journal :
- Biomedicines
- Accession number :
- edsair.doi.dedup.....a2818e478b2a94564bdac22ed3730831