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Possible Interactions between Malaria, Helminthiases and the Gut Microbiota: A Short Review

Possible Interactions between Malaria, Helminthiases and the Gut Microbiota: A Short Review

Authors :
Jean d’Amour Mutoni
Jean-Paul Coutelier
Nadine Rujeni
Leon Mutesa
Patrice D. Cani
UCL - SSS/DDUV - Institut de Duve
UCL - SSS/DDUV/MEXP - Médecine expérimentale
UCL - SSS/LDRI - Louvain Drug Research Institute
Source :
Microorganisms, Vol. 10, no.4, p. 721 [1-10] (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Malaria, caused by the Plasmodium species, is an infectious disease responsible for more than 600 thousand deaths and more than 200 million morbidity cases annually. With above 90% of those deaths and cases, sub-Saharan Africa is affected disproportionately. Malaria clinical manifestations range from asymptomatic to simple, mild, and severe disease. External factors such as the gut microbiota and helminthiases have been shown to affect malaria clinical manifestations. However, little is known about whether the gut microbiota has the potential to influence malaria clinical manifestations in humans. Similarly, many previous studies have shown divergent results on the effects of helminths on malaria clinical manifestations. To date, a few studies, mainly murine, have shown the gut microbiota’s capacity to modulate malaria’s prospective risk of infection, transmission, and severity. This short review seeks to summarize recent literature about possible interactions between malaria, helminthiases, and the gut microbiota. The knowledge from this exercise will inform innovation possibilities for future tools, technologies, approaches, and policies around the prevention and management of malaria in endemic countries.

Details

Language :
English
Database :
OpenAIRE
Journal :
Microorganisms, Vol. 10, no.4, p. 721 [1-10] (2022)
Accession number :
edsair.doi.dedup.....a290bac386aae87acd96341d2f882e4f