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Porcine soluble CD83 alleviates LPS-induced abortion in mice by promoting Th2 cytokine production, Treg cell generation and trophoblast invasion
- Source :
- Theriogenology. 157:149-161
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- CD83, either in its membrance-bound form (mCD83) or soluble form (sCD83), is an important immunomodulatory molecule in humans and mice. While mCD83 is immunostimulatory, sCD83 exhibits striking immunosuppressive activities, suggesting that sCD83 may be used to combat inflammatory diseases, such as rheumatoid arthritis, graft-versus-host disease and habitual abortion. Although many studies had shed lights on the role of CD83 in humans and mice, little is known about CD83 in other animals. Recently, we showed that porcine CD83 had similar biochemical characteristics and immunoregulatory functions as its human counterpart. However, whether porcine sCD83 (psCD83) is involved in maintaining the immunological tolerance at the maternal-fetal interface and thereby prevents embryo loss and abortion during pregnancy is unclear. In this study, we used LPS-induced animal model to analyze the effect of porcine sCD83 on the mouse abortion. Results showed that psCD83 could significantly alleviate LPS-induced abortion in mice, indicating that the psCD83 had the function of fetal protection. Mechanically, psCD83-mediated fetal protection was related to the promotion on Th2 cytokine production, Treg cell differentiation and trophoblast invasion. This study provides a molecular basis for the fetal protection of psCD83, as well as a potential target for the regulation of maternal-fetal interfacial immune tolerance.
- Subjects :
- Lipopolysaccharides
Swine
Immunoglobulins
Disease
Abortion
Biology
T-Lymphocytes, Regulatory
Immune tolerance
Rodent Diseases
Mice
Food Animals
Antigens, CD
Pregnancy
medicine
Animals
Small Animals
Swine Diseases
Fetus
Membrane Glycoproteins
Equine
Trophoblast
Dendritic Cells
Abortion, Veterinary
medicine.disease
Trophoblasts
medicine.anatomical_structure
Rheumatoid arthritis
embryonic structures
Immunology
Cytokines
Female
Animal Science and Zoology
Function (biology)
Subjects
Details
- ISSN :
- 0093691X
- Volume :
- 157
- Database :
- OpenAIRE
- Journal :
- Theriogenology
- Accession number :
- edsair.doi.dedup.....a2aa4bada16e2dd4a1c473da8982b4bb