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Hemoglobin E Hemoglobinopathy in an Adult from Assam with Unusual Presentation: A Diagnostic Dilemma
- Source :
- Journal of Laboratory Physicians, Vol 8, Iss 02, Pp 116-119 (2016), Journal of Laboratory Physicians
- Publication Year :
- 2016
- Publisher :
- Thieme Medical and Scientific Publishers Pvt. Ltd., 2016.
-
Abstract
- Hemoglobin E (HbE) is estimated to affect at least one million people around the world. Carrier frequency of hemoglobin E/β-thalassemia (HbE/β-thalassemia) is highest in Southeast Asia, reaching as high as 60% in parts of Thailand, Laos, and Cambodia. In the Indian subcontinent, highest frequency is observed in The Northeast regions, but relatively rare in rest of the country. Increasing migration of population from highly affected areas is resulting in rising prevalence in The South and other parts of India. HbE/β-thalassemia is characterized by marked clinical diversity, phenotypic instability, and age-related changes in adaptation to anemia. This paper reports a case of HbE disease in an adult immigrant from Assam and documents the difficulties encountered in the definitive subtyping of HbE hemoglobinopathy. Distinguishing between homozygous HbE disease and HbE/β-thalassemia is a challenge to hematopathologist as both are clinically and hematologically similar.
- Subjects :
- 0301 basic medicine
Pediatrics
medicine.medical_specialty
hemoglobin e/β-thalassemia
Anemia
030106 microbiology
030231 tropical medicine
Population
clinical diversity
lcsh:Medicine
Case Report
Diagnostic dilemma
Southeast asia
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
parasitic diseases
medicine
adaptation to anemia
education
education.field_of_study
Carrier signal
business.industry
phenotypic instability
lcsh:R
virus diseases
medicine.disease
digestive system diseases
Indian subcontinent
Hemoglobinopathy
Hemoglobin E
business
Subjects
Details
- Language :
- English
- ISSN :
- 09747826 and 09742727
- Volume :
- 8
- Issue :
- 02
- Database :
- OpenAIRE
- Journal :
- Journal of Laboratory Physicians
- Accession number :
- edsair.doi.dedup.....a2c652d2d1b250d07d5451633c742042