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Intravenous immunoglobulin for the treatment of Crohn's disease
- Source :
- Autoimmunity Reviews. (2):275-280
- Publisher :
- Elsevier B.V.
-
Abstract
- Crohn's disease (CD) is a debilitating condition which still requires improvement in its management. There is a need for alternatives to anti-tumour necrosis factor drugs which are costly and beneficial in less than 50% of patients. Intravenous immunoglobulin (IVIG) has been used in the management of aminosalicylate- and steroid-resistant CD for more than 20years, although the published literature available is limited. A literature search identified 17 relevant publications since 1969, including five case reports of single patients, two abstracts, three conference papers, one review paper and six book or journal articles. No randomised controlled trials of IVIG in CD have been published. A review of the evidence identified indicates that IVIG can induce a rapid and significant improvement in aminosalicylate- and steroid-resistant CD, often within days of the initial administration. Data from longer-term studies show that maintenance of remission over the medium term is also possible. These encouraging findings provide a rationale for the initiation of larger randomised controlled trials of IVIG in CD with the aim of providing further treatment options for this difficult-to-manage condition.
- Subjects :
- medicine.medical_specialty
Immunology
MEDLINE
Disease
Review
Inflammatory bowel disease
Aminosalicylate
Medium term
Anti-TNF
Crohn Disease
Internal medicine
medicine
Humans
Immunologic Factors
Immunology and Allergy
Intravenous immunoglobulin
Crohn's disease
biology
business.industry
Enterovesical fistula
Immunoglobulins, Intravenous
medicine.disease
Treatment Outcome
Meta-analysis
biology.protein
Antibody
business
Subjects
Details
- Language :
- English
- ISSN :
- 15689972
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Autoimmunity Reviews
- Accession number :
- edsair.doi.dedup.....a2f2a9e9a4a8db7be7b922c1dd9749de
- Full Text :
- https://doi.org/10.1016/j.autrev.2012.04.006