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Cardiovascular disease in primary sjögren’s syndrome
- Publication Year :
- 2018
-
Abstract
- Background A close relationship between rheumatic diseases and cardiovascular disease (CVD) has been reported, accounting for the higher mortality and morbidity observed in these patients. In the last years, it has been clearly reported that patients affected by primary Sjogren's syndrome (pSS) experienced an increased risk of CVD. Objective This review aimed at investigating CVD, traditional cardiovascular (CV) risk factors and possible targeted therapeutic strategies in pSS patients. Method Available literature concerning CV risk factors in pSS patients has been selected and discussed. Conclusion Disease-related characteristics and traditional CV risk factors contribute to observed atherosclerotic damage in pSS patients. The pro-inflammatory mediators together with hypertension and type 2 diabetes, which are more prevalent in pSS patients, determine the increased CV burden. Future studies are needed to fully elucidate the role of possible targeted therapies.
- Subjects :
- medicine.medical_specialty
Future studies
Endothelial damage
Disease
Type 2 diabetes
Comorbidity
030204 cardiovascular system & hematology
Sjögren syndrome
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Medicine
Humans
030212 general & internal medicine
Pharmacology
business.industry
Risk Factor
General Medicine
medicine.disease
Atherosclerosis
Cardiovascular disease
Cardiovascular risk
stomatognathic diseases
Settore MED/16 - Reumatologia
Increased risk
Sjogren's Syndrome
Close relationship
Cardiovascular Diseases
Atherosclerosi
Sjogren s
business
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a2f719d4ab5ec97fc9413c491100fc7b