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Schizandrin reverses memory impairment in rats
- Source :
- Phytotherapy Research. 22:49-52
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- The present study investigated the effect of schizandrin, a component of the fruit of Schizandra chinesis Baill (Fructus Schizandrae), on memory impairment in rats. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, markedly impaired spatial memory in an eight-arm radial maze. A higher dose of scopolamine (3 mg/kg, i.p.) also impaired the passive avoidance response. Schizandrin (1 and 10 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of spatial memory. Similarly, schizandrin (1 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of the passive avoidance response. Moreover, in mice, schizandrin (1 and 10 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist. Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits.
- Subjects :
- Male
Agonist
medicine.drug_class
Scopolamine
Muscarinic Antagonists
Pharmacology
Lignans
Cyclooctanes
Muscarinic acetylcholine receptor
Avoidance Learning
medicine
Oxotremorine
Animals
Memory impairment
Polycyclic Compounds
Rats, Wistar
Maze Learning
Schisandra
Memory Disorders
Dose-Response Relationship, Drug
Molecular Structure
Chemistry
Alkaloid
Antagonist
Rats
Dose–response relationship
Anesthesia
Cholinergic
Phytotherapy
medicine.drug
Subjects
Details
- ISSN :
- 10991573 and 0951418X
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Phytotherapy Research
- Accession number :
- edsair.doi.dedup.....a2fc090e0264b3098c15be547dc3f942