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The role of Fibroscan in predicting the presence of varices in patients with cirrhosis
- Source :
- European Journal of Gastroenterology & Hepatology. 27:1307-1312
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Background/aim Transient elastography is a relatively new, noninvasive method of measuring liver stiffness. This study aimed to evaluate the diagnostic accuracy of transient elastography and other noninvasive methods for the diagnosis of esophageal varices (EV) in patients with cirrhosis. Methods This cross-sectional study graded EV according to size in 145 consecutive patients with cirrhosis who underwent endoscopy, Fibroscan, and other noninvasive diagnostic methods. The accuracy of these diagnostic methods in diagnosing EV was evaluated on the basis of area under receiver operating characteristic (AUROC) curves. Results Elastography was successful in 123 patients. Of these, 54.5% had hepatitis C and 10.6% had hepatitis B. EV were absent in 39.8%, small EV was present in 24.4%, and large EV was present in 35.8% of patients. Fibroscan, aspartate aminotransferase-to-platelet ratio index, and international normalized ratio showed low accuracy in diagnosing EV in non-viral-related cirrhosis patients (AUROCs 0.66, 0.68, and 0.67, respectively). Fibroscan and aspartate aminotransferase-to-platelet ratio index were more accurate in measuring EV with a viral etiology (AUROCs 0.704 and 0.703, respectively). A cutoff value of 16.9 kPa was 83.8% sensitive in diagnosing EV in non-viral-cirrhotic patients, whereas a cutoff value of 19.9 kPa was 83.4% sensitive in diagnosing EV in patients with viral hepatitis. Fibroscan was moderately accurate in diagnosing grade I EV and less accurate in diagnosing grades II and III EV in all cirrhotic patients, irrespective of the underlying etiology. Conclusion Fibroscan might be useful in predicting the presence of EV in patients with cirrhosis with a viral etiology. However, endoscopy remains the gold standard for EV screening.
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Esophageal and Gastric Varices
Severity of Illness Index
Gastroenterology
Endoscopy, Gastrointestinal
Hepatitis B, Chronic
Esophageal varices
Predictive Value of Tests
Internal medicine
medicine
Humans
Aspartate Aminotransferases
International Normalized Ratio
Aged
Retrospective Studies
Hepatology
medicine.diagnostic_test
Platelet Count
business.industry
Hepatitis C
Hepatitis C, Chronic
Middle Aged
Hepatitis B
medicine.disease
Cross-Sectional Studies
Liver
ROC Curve
Area Under Curve
Predictive value of tests
Elasticity Imaging Techniques
Female
Elastography
Transient elastography
business
Viral hepatitis
Subjects
Details
- ISSN :
- 0954691X
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- European Journal of Gastroenterology & Hepatology
- Accession number :
- edsair.doi.dedup.....a31b43ce00add049cc550a84daf1eb64