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A resource of targeted mutant mouse lines for 5,061 genes
- Source :
- Nature Genetics, Nature Genetics, Nature Publishing Group, 2021, ⟨10.1038/s41588-021-00825-y⟩, Nature genetics, vol 53, iss 4, Nature genetics 53(4), 416-419 (2021). doi:10.1038/s41588-021-00825-y, Nature genetics (Online) 53 (2021): 416–419. doi:10.1038/s41588-021-00825-y, info:cnr-pdr/source/autori:Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y; International Mouse Phenotyping Consortium (IMPC), Teboul L, Murray SA./titolo:A resource of targeted mutant mouse lines for 5,061 genes/doi:10.1038%2Fs41588-021-00825-y/rivista:Nature genetics (Online)/anno:2021/pagina_da:416/pagina_a:419/intervallo_pagine:416–419/volume:53, Nat. Genet. 53, 416-419 (2021), Nat Genet
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for over 5,000 genes from targeted embryonic stem cells on the C57BL/6N genetic background. This includes 2,850 null alleles for which no equivalent mutant mouse line exists, 2,987 novel conditional-ready alleles, and 4,433 novel reporter alleles. This nearly triples the number of genes with reporter alleles and almost doubles the number of conditional alleles available to the scientific community. When combined with more than 30 years of community effort, the total mutant allele mouse resource covers more than half of the genome. The extensively validated collection is archived and distributed through public repositories, facilitating availability to the worldwide biomedical research community, and expanding our understanding of gene function and human disease.
- Subjects :
- Cancer Research
Genotype
Knockout
International Cooperation
[SDV]Life Sciences [q-bio]
Mutant
Mutagenesis (molecular biology technique)
cytology [Mouse Embryonic Stem Cells]
Mouse Mutant Strains
Biology
Genome
Medical and Health Sciences
Article
03 medical and health sciences
Mice
0302 clinical medicine
Research community
ddc:570
Genetics
Animals
Allele
Gene
Genetic Association Studies
030304 developmental biology
Mice, Knockout
0303 health sciences
Internet
metabolism [Mouse Embryonic Stem Cells]
Information Dissemination
mutant mouse IMPC
Mouse Embryonic Stem Cells
Biological Sciences
Null allele
Embryonic stem cell
Phenotype
Mutagenesis
Montertondo Mouse Production
Technology Platforms
International Mouse Phenotyping Consortium
Function (biology)
030217 neurology & neurosurgery
Gene Deletion
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 10614036 and 15461718
- Database :
- OpenAIRE
- Journal :
- Nature Genetics, Nature Genetics, Nature Publishing Group, 2021, ⟨10.1038/s41588-021-00825-y⟩, Nature genetics, vol 53, iss 4, Nature genetics 53(4), 416-419 (2021). doi:10.1038/s41588-021-00825-y, Nature genetics (Online) 53 (2021): 416–419. doi:10.1038/s41588-021-00825-y, info:cnr-pdr/source/autori:Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y; International Mouse Phenotyping Consortium (IMPC), Teboul L, Murray SA./titolo:A resource of targeted mutant mouse lines for 5,061 genes/doi:10.1038%2Fs41588-021-00825-y/rivista:Nature genetics (Online)/anno:2021/pagina_da:416/pagina_a:419/intervallo_pagine:416–419/volume:53, Nat. Genet. 53, 416-419 (2021), Nat Genet
- Accession number :
- edsair.doi.dedup.....a328a0f6c9b44a9da9baebf9bee6ffa8
- Full Text :
- https://doi.org/10.1038/s41588-021-00825-y⟩