Analytic morphomics: a novel CT imaging approach to quantify adipose tissue and muscle composition in allogeneic hematopoietic cell transplantation

Analytic morphomics is a novel methodology that uses high-throughput computed tomography (CT) processing techniques to generate reproducible body measurements (Supplementary Table).1, 2, 3, 4 Body mass index is widely used in clinical and public health studies to predict mortality risk.5 Indeed, we recently examined its impact in allogeneic hematopoietic cell transplantation (HCT) and found that obese patients were at significantly greater risk of mortality compared with normal weight individuals.6 Unfortunately, body mass index does not reliably distinguish adipose tissue mass from muscle mass.7 Therefore, we sought to index patient size using CT measurements.2 The aim of the current study was to apply analytic morphomics in a cohort of allogeneic HCT patients and correlate with clinical outcomes.