Back to Search
Start Over
Molecular Changes of Lung Malignancy in HIV Infection
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018), Scientific Reports
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Malignancy of the lung is a major source of morbidity and mortality in persons with human immunodeficiency virus infection; as the most prevalent non-acquired immunodeficiency syndrome-defining malignancy, it represents an important and growing problem confronting HIV-infected patients. To evaluate the molecular changes of lung malignancy in HIV infection, we analyzed differential gene expression profiles and screened for early detection biomarkers of HIV-associated lung cancer using Affymetrix arrays and IPA analysis. A total of 59 patients were diagnosed with HIV-associated lung cancer from Jan 2010 to May 2018. The primary outcome was a significant difference in survival outcome between stages III-IV (10.46 ± 1.87 months) and I-II (17.66 ± 2.88 months). We identified 758 differentially expressed genes in HIV-associated lung cancer. The expression levels of SIX1 and TFAP2A are specifically increased in HIV-associated lung cancer and are associated with poorly differentiated tumor tissue. We also found decreased ADH1B, INMT and SYNPO2 mRNA levels in HIV lung cancer. A comprehensive network and pathway analysis of the dysregulated genes revealed that these genes were associated with four network functions and six canonical pathways relevant to the development of HIV-associated lung cancer. The molecular changes in lung malignancy may help screen the growing population of HIV patients who have or will develop this malignancy.
- Subjects :
- Male
0301 basic medicine
Oncology
Lung Neoplasms
lcsh:Medicine
HIV Infections
0302 clinical medicine
Gene Regulatory Networks
Prospective Studies
Prospective cohort study
lcsh:Science
Immunodeficiency
education.field_of_study
Multidisciplinary
Microfilament Proteins
Middle Aged
Gene Expression Regulation, Neoplastic
medicine.anatomical_structure
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Female
Metabolic Networks and Pathways
Adult
medicine.medical_specialty
Population
Adenocarcinoma
Malignancy
Article
03 medical and health sciences
Internal medicine
medicine
Carcinoma
Humans
RNA, Messenger
Lung cancer
education
Survival analysis
Aged
Neoplasm Staging
Homeodomain Proteins
Lung
business.industry
Gene Expression Profiling
lcsh:R
Alcohol Dehydrogenase
Methyltransferases
medicine.disease
Small Cell Lung Carcinoma
Survival Analysis
030104 developmental biology
Transcription Factor AP-2
lcsh:Q
business
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....a3509ad35fb383fc2a7fd3fc5bdfaa0c