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Plasma Lutein and Zeaxanthin and Other Carotenoids as Modifiable Risk Factors for Age-Related Maculopathy and Cataract: The POLA Study
- Source :
- Investigative Ophthalmology & Visual Science, Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2006, 47 (6), pp.2329-35. ⟨10.1167/iovs.05-1235⟩, Investigative Ophthalmology & Visual Science, 2006, 47 (6), pp.2329-35. ⟨10.1167/iovs.05-1235⟩
- Publication Year :
- 2006
- Publisher :
- Association for Research in Vision and Ophthalmology (ARVO), 2006.
-
Abstract
- PURPOSE. To assess the associations of plasma lutein and zeaxanthin and other carotenoids with the risk of age-related maculopathy (ARM) and cataract in the population-based Pathologies Oculaires Liees a l'Age (POLA) Study. METHODS. Retinal photographs were graded according to the international classification. ARM was defined by the presence of late ARM (neovascular ARM, geographic atrophy) and/or soft indistinct drusen (>125 μm) and/or soft distinct drusen (>125 μm) associated with pigmentary abnormalities. Cataract classification was based on a direct standardized lens examination at the slit lamp, according to Lens Opacities Classification System III. Plasma carotenoids were measured by high-performance liquid chromatography (HPLC), in 899 subjects of the cohort. RESULTS. After multivariate adjustment, the highest quintile of plasma zeaxanthin was significantly associated with reduced risk of ARM (OR = 0.07; 95% CI: 0.01-0.58; P for trend = 0.005), nuclear cataract (OR = 0.23; 95% CI: 0.08-0.68; P for trend = 0.003) and any cataract (OR = 0.53; 95% CI: 0.31-0.89; P for trend = 0.01). ARM was significantly associated with combined plasma lutein and zeaxanthin (OR = 0.21; 95% CI: 0.05- 0.79; P for trend = 0.01), and tended to be associated with plasma lutein (OR = 0.31; 95% CI: 0.09-1.07; P for trend = 0.04), whereas cataract showed no such associations. Among other carotenoids, only β-carotene showed a significant negative association with nuclear cataract, but not ARM. CONCLUSIONS. These results are strongly suggestive of a protective role of the xanthophylls, in particular zeaxanthin, for the protection against ARM and cataract.
- Subjects :
- Male
Lutein
genetic structures
030309 nutrition & dietetics
Xanthophylls
MESH: Research Support, Non-U.S. Gov't
Macular Degeneration
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
MESH: Risk Factors
Chromatography, High Pressure Liquid
0303 health sciences
education.field_of_study
MESH: Middle Aged
[SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology
[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology
food and beverages
Middle Aged
beta Carotene
Zeaxanthin
[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs
MESH: beta Carotene
Female
medicine.medical_specialty
Population
Drusen
MESH: Lutein
Cataract
03 medical and health sciences
Zeaxanthins
Ophthalmology
medicine
Humans
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Risk factor
MESH: Chromatography, High Pressure Liquid
education
MESH: Macular Degeneration
MESH: Humans
business.industry
MESH: Xanthophylls
Macular degeneration
medicine.disease
MESH: Male
eye diseases
Surgery
Age-related maculopathy
chemistry
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
030221 ophthalmology & optometry
Maculopathy
MESH: Cataract
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
sense organs
business
MESH: Female
Subjects
Details
- ISSN :
- 15525783 and 01460404
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Investigative Opthalmology & Visual Science
- Accession number :
- edsair.doi.dedup.....a352e15760ff4179fd8e52e265a31359