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High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss

Authors :
June Hur
Hyung Jin Choi
Dae Ho Lee
Han Seok Choi
Jin Ku Kang
Kyong Soo Park
Seung Soon Im
Young-Bum Kim
Cheolsoo Choi
Young Jae Lee
Young Joo Park
Sun Wook Cho
Hyeonjin Kim
Ji-Young Cha
Cheol Soon Lee
Jinwook Lee
Carmen J. Booth
Joong Hyuck Auh
Byung-Chul Oh
Jung-Wan Kim
Ok Hee Kim
Jun Young Yang
Publication Year :
2019
Publisher :
Cold Spring Harbor Laboratory, 2019.

Abstract

Phosphate overload contributes to mineral bone disorders associated with crystal nephropathies. Phytate, the major form of phosphorus in plant seeds, is known as an indigestible and negligible in humans. However, the mechanism and adverse effects of high-phytate intake on Ca2+and phosphate absorption and homeostasis are unknown. Here we show that excessive intake of phytate with a low-Ca2+diet fed to rats contributed to the development of crystal nephropathies, renal phosphate wasting, and bone loss through tubular dysfunction secondary to dysregulation of intestinal calcium and phosphate absorption. Moreover, Ca2+supplementation alleviated the detrimental effects of excess dietary phytate on bone and kidney through excretion of undigested Ca2+-phytate, which prevented a vicious cycle of intestinal phosphate overload and renal phosphate wasting while improving intestinal Ca2+bioavailability. Thus, we demonstrate that phytate is digestible without a high-Ca2+diet and a risk factor for phosphate overloading and developing crystal nephropathies and bone disease.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....a35866facd54dbb5695c338fa1c2c779
Full Text :
https://doi.org/10.1101/816512