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99mTc-sestamibi SPECT/CT for the characterization of renal masses: a pictorial guide
- Source :
- The British Journal of Radiology. :20170526
- Publication Year :
- 2018
- Publisher :
- British Institute of Radiology, 2018.
-
Abstract
- In parallel to the increased utilization of cross-sectional imaging, the incidence of small renal masses has steadily risen in recent years. At the present time, anatomical imaging techniques are limited in their ability to differentiate benign from malignant renal masses. Moreover, renal mass biopsy has a high non-diagnostic rate, poor negative-predictive ability, and carries potential risks as well as substantial costs. As a result, benign renal masses are often unnecessarily resected for the false presumption of cancer. (99m)Tc-sestamibi single photon emission computed tomography/computed tomography (SPECT/CT) is a molecular imaging test that allows for the differentiation of benign renal oncocytomas and hybrid oncocytomic/chromophobe tumours apart from malignant renal cell carcinomas on the basis of differences in mitochondrial content as well as multidrug resistant pump expression. Herein, we review the principles of (99m)Tc-sestamibi SPECT/CT administration and image interpretation for the purpose of renal mass characterization.
- Subjects :
- medicine.medical_specialty
medicine.diagnostic_test
business.industry
030232 urology & nephrology
Cancer
Pictorial Review
General Medicine
Chromophobe cell
urologic and male genital diseases
medicine.disease
99mTc Sestamibi
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Biopsy
medicine
Renal mass
Radiology, Nuclear Medicine and imaging
Radiology
Tomography
Molecular imaging
Technetium Tc 99m Sestamibi
business
Subjects
Details
- ISSN :
- 1748880X and 00071285
- Database :
- OpenAIRE
- Journal :
- The British Journal of Radiology
- Accession number :
- edsair.doi.dedup.....a35d731d81037cc500545540f9726718
- Full Text :
- https://doi.org/10.1259/bjr.20170526