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Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic
- Source :
- Nature communications. 13(1)
- Publication Year :
- 2021
-
Abstract
- Cholera is a life-threatening infectious disease that remains an important public health issue in several low and middle-income countries. In 1992, a newly identified O139 Vibrio cholerae temporarily displaced the O1 serogroup. No study has been able to answer why the potential eighth cholera pandemic (8CP) causing V. cholerae O139 emerged so successfully and then died out. We conducted a genomic study, including 330 O139 isolates, covering emergence of the serogroup in 1992 through to 2015. We noted two key genomic evolutionary changes that may have been responsible for the disappearance of genetically distinct but temporally overlapping waves (A-C) of O139. Firstly, as the waves progressed, a switch from a homogenous toxin genotype in wave-A to heterogeneous genotypes. Secondly, a gradual loss of antimicrobial resistance (AMR) with the progression of waves. We hypothesize that these two changes contributed to the eventual epidemiological decline of O139.
- Subjects :
- Cholera Toxin
Multidisciplinary
45
631/208/212/2306
631/326/41/2529
45/43
article
General Physics and Astronomy
General Chemistry
bacterial infections and mycoses
General Biochemistry, Genetics and Molecular Biology
Vibrio cholerae O139
Cholera
692/699/255/1318
Humans
631/326/41/2530
Pandemics
Vibrio cholerae
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature communications
- Accession number :
- edsair.doi.dedup.....a376300e05918474ebb64249da7a295c