Back to Search
Start Over
Oats Do Not Induce Systemic or Mucosal Autoantibody Response in Children With Coeliac Disease
- Publication Year :
- 2009
-
Abstract
- Objectives: A gluten-free diet omitting wheat, rye, and barley is the only effective treatment for coeliac disease. The necessity of excluding oats from the diet has remained controversial. We studied the toxicity of oats in children with coeliac disease during a 2-year follow-up by investigating jejunal transglutaminase 2 (TG2)-targeted IgA-class autoantibody deposits, a potentially more sensitive disease marker than serum antibodies or conventional histology. Patients and Methods: Twenty-three coeliac children in remission were randomized to undergo oat or gluten challenge with wheat, rye, barley, and oats. When jejunal histological relapse was evident after gluten challenge, patients excluded wheat, rye, and barley but continued with oats. Mucosal morphology and TG2-targeted autoantibody deposits were studied in jejunal biopsies taken at baseline and after 6 and 24 months. Furthermore, serum IgA-class TG2 antibodies were measured. Results: At baseline, serum TG2 antibodies were negative in all 23 patients, but 7 of them had minor mucosal deposits. In the oats group, there was no significant change in the intensity of the deposits within 2 years. In contrast, during the gluten challenge, the intensity of the deposits clearly increased and decreased again when wheat, rye, and barley were excluded but consumption of oats was continued; this was in line with serum autoantibodies. The intensity of the mucosal deposits correlated well with both villous morphology and serum autoantibody levels. Conclusions: Consumption of oats does not induce TG2 autoantibody production at mucosal level in children with coeliac disease. Measurement of small-intestinal mucosal autoantibody deposits is suitable for monitoring treatment in coeliac patients.
- Subjects :
- Male
Immunoglobulin A
food.ingredient
Adolescent
Avena
Tissue transglutaminase
Klinikai orvostudományok
Coeliac disease
Diet, Gluten-Free
food
Intestinal mucosa
GTP-Binding Proteins
Immunopathology
Humans
Medicine
Protein Glutamine gamma Glutamyltransferase 2
Intestinal Mucosa
Child
Autoantibodies
Plant Proteins
chemistry.chemical_classification
Transglutaminases
biology
business.industry
Gastroenterology
Autoantibody
food and beverages
Orvostudományok
medicine.disease
Gluten
Celiac Disease
Jejunum
Treatment Outcome
chemistry
Seeds
Pediatrics, Perinatology and Child Health
Immunology
biology.protein
Female
Edible Grain
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a38c65d50c8fbbe81d593b5756161702