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Ebolavirus and Marburgvirus: Insight the Filoviridae family

Authors :: Alessio Bocedi
Paolo Ascenzi
Giuseppe Ippolito
Maria Rosaria Capobianchi
Julia Heptonstall
Antonino Di Caro
Eloise Mastrangelo
Martino Bolognesi
Ascenzi, Paolo
Bocedi, A
Heptonstall, J
Capobianchi, Mr
DI CARO, A
Mastrangelo, E
Bolognesi, M
Ippolito, G.
Source :: Molecular aspects of medicine 29 (2008): 151–185. doi:10.1016/j.mam.2007.09.005, info:cnr-pdr/source/autori:Ascenzi, P; Bocedi, A; Heptonstall, J; Capobianchi, MR; Di Caro, A; Mastrangelo, E; Bolognesi, M; Ippolito, G/titolo:Ebolavirus and Marburgvirus: Insight the Filoviridae family/doi:10.1016%2Fj.mam.2007.09.005/rivista:Molecular aspects of medicine/anno:2008/pagina_da:151/pagina_a:185/intervallo_pagine:151–185/volume:29
Publication Year :: 2008
Publisher :: Elsevier BV, 2008.
Abstract: Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins. No significant homology is observed between filovirus proteins and any known macromolecule. Moreover, Marburgvirus and Ebolavirus show significant differences in protein homology. The natural maintenance cycle of filoviruses is unknown, the natural reservoir, the mode of transmission, the epidemic disease generation, and temporal dynamics are unclear. Lastly, Ebolavirus and Marburgvirus are considered as potential biological weapons. Vaccine appears the unique therapeutic frontier. Here, molecular and clinical aspects of filoviral haemorrhagic fevers are summarized. (c) 2007 Published by Elsevier Ltd.