Back to Search
Start Over
Assessment of subclinical left ventricular dysfunction with speckle-tracking echocardiography in hyperthyroid and euthyroid Graves' disease and its correlation with serum TIMP-1
- Source :
- Acta cardiologica. 76(2)
- Publication Year :
- 2020
-
Abstract
- Background Graves' disease has a multitude of effects on the cardiovascular system. In the detection of subclinical left ventricular dysfunction, speckle-tracking echocardiography is more useful than conventional echocardiography. The aim of the present study was to compare the longitudinal global strain values and venous blood concentration of (tissue inhibitor of metalloproteinase-1) TIMP-1, a regulator of the extracellular matrix, among hyperthyroid patients with Graves' disease, euthyroid patients with Graves' disease and healthy control subjects. Materials and methods The study enrolled 40 hyperthyroid patients with newly diagnosed Graves' disease, 40 patients with Graves' disease who were euthyroid for at least 6 months and 40 control subjects with normal thyroid function. Participants underwent conventional echocardiography and speckle-tracking echocardiography to obtain segmental and global longitudinal strain values. In addition, the serum TIMP-1 value was assessed in the venous blood samples of the participants. Results The hyperthyroid Graves' patients showed greater serum TIMP-1 levels versus the control group and the euthyroid Graves' group. Compared to the control group, the TIMP-1 level was also significantly higher in the euthyroid Graves' group. Lower GLS (global longitudinal strain) average and GLS2C, GLS3C, GLS4C values were observed in both the hyperthyroid and euthyroid Graves' patients compared to the control group. The euthyroid Graves' patients and hyperthyroid Graves' patients had similar GLS values. The serum TIMP-1 level was negatively correlated with global strain values. Conclusion Graves' disease coexists with impaired segmental and global longitudinal strain and increased TIMP-1 levels. This coexistence seems to be independent of serum thyroid hormone levels.
- Subjects :
- endocrine system
medicine.medical_specialty
endocrine system diseases
Graves' disease
Speckle tracking echocardiography
Disease
030204 cardiovascular system & hematology
Hyperthyroidism
03 medical and health sciences
Ventricular Dysfunction, Left
0302 clinical medicine
Internal medicine
medicine
Humans
Euthyroid
030212 general & internal medicine
Subclinical infection
Tissue Inhibitor of Metalloproteinase-1
business.industry
Thyroid
General Medicine
Venous blood
medicine.disease
eye diseases
Graves Disease
medicine.anatomical_structure
Echocardiography
Cardiology
Cardiology and Cardiovascular Medicine
business
hormones, hormone substitutes, and hormone antagonists
Hormone
Subjects
Details
- ISSN :
- 1784973X
- Volume :
- 76
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Acta cardiologica
- Accession number :
- edsair.doi.dedup.....a3bd445ddafc1080ee4dbf72195941f2