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Multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: the MSKCC nomogram and the Tenon score. Results of the NOTEGS study
- Source :
- British Journal of Cancer
- Publication Year :
- 2016
-
Abstract
- Background: The purpose of this study was to prospectively evaluate the combined use of The Memorial Sloan Kettering Cancer Center nomogram and Tenon score to select, in patients with metastatic sentinel lymph node (SN), those at low risk of metastatic non-SN for whom additional axillary lymph node dissection (ALND) could be avoided. Methods: From January 2011 to July 2012, a prospective non-interventional nationwide study was conducted (NCT01509963). We sought to identify the false reassurance rate (FRR, a negative test result is false) in patients with both a ⩽10% probability of metastatic non-SN with the MSKCC nomogram and a Tenon score ⩽3.5 (low risk): the proportion of patients with metastatic non-SN at additional ALND. Our hypothesis was that these patients would have a FRR⩽5%. Results: Data on 2822 patients with breast cancer from 53 institutions were prospectively recorded. At least one SN was metastatic (isolated tumour cells, micro- or macrometastases) in 696 patients (24.7%). Among patients with ALND and complete data to calculate combined risk (n=504), 67 and 437 patients had low and high combined risk, respectively. Patients at low risk had less ALND (47%) compared to patients at high risk (P
- Subjects :
- 0301 basic medicine
Oncology
Adult
Cancer Research
medicine.medical_specialty
Sentinel lymph node
Breast Neoplasms
03 medical and health sciences
0302 clinical medicine
Breast cancer
breast cancer
sentinel lymph node
Internal medicine
medicine
Humans
Lung cancer
Prospective cohort study
Aged
Cervical cancer
Aged, 80 and over
business.industry
Sentinel Lymph Node Biopsy
Axillary Lymph Node Dissection
Cancer
prediction
Nomogram
Middle Aged
medicine.disease
Prognosis
de-escalation
Nomograms
030104 developmental biology
030220 oncology & carcinogenesis
Lymphatic Metastasis
Clinical Study
Lymph Node Excision
Female
Lymph Nodes
business
mathematical models
non-sentinel lymph node metastasis
Subjects
Details
- ISSN :
- 15321827
- Volume :
- 116
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- British journal of cancer
- Accession number :
- edsair.doi.dedup.....a3c2c769a031be85b697d15798ff6cb5