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Effects of Growth Hormone-Releasing Hormone and Corticotropin-Releasing Hormone on the Release of Thyrotropin-Releasing Hormone from the Rat Hypothalamus in Vitro
- Source :
- Experimental and Clinical Endocrinology & Diabetes. 90:365-368
- Publication Year :
- 2009
- Publisher :
- Georg Thieme Verlag KG, 2009.
-
Abstract
- Effects of growth hormone-releasing hormone (GRH) and corticotropin-releasing hormone (CRH) on the release of immunoreactive thyrotropin-releasing hormone (ir-TRH) from the rat hypothalamus in vitro were studied. The rat hypothalamus was incubated in medium 199 with 1.0 mg/ml of bacitracin (pH 7.4) for 20 min. The amount of ir-TRH release into the medium was measured by radioimmunoassay. The ir-TRH release from the rat hypothalamus was inhibited significantly in a dose-related manner with the addition of GRH or CRH. These findings suggest that GRH and CRH inhibit ir-TRH release from the rat hypothalamus in vitro.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
endocrine system diseases
Somatotropic cell
Corticotropin-Releasing Hormone
Endocrinology, Diabetes and Metabolism
Hypothalamus
Thyrotropin-releasing hormone
Growth Hormone-Releasing Hormone
Gonadotropic cell
Corticotropin-releasing hormone
Endocrinology
Thyrotropin-releasing hormone receptor
Internal medicine
Internal Medicine
medicine
Animals
Thyrotropin-Releasing Hormone
Chemistry
Rats, Inbred Strains
General Medicine
Chromatography, Ion Exchange
Growth hormone–releasing hormone
Rats
nervous system
Corticotropic cell
hormones, hormone substitutes, and hormone antagonists
Endocrine gland
Subjects
Details
- ISSN :
- 14393646 and 09477349
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Experimental and Clinical Endocrinology & Diabetes
- Accession number :
- edsair.doi.dedup.....a3de29552f79aef0bb1a3a2028bcf2d3