Back to Search
Start Over
Epigenetics and Inflammation in Diabetic Nephropathy
- Source :
- Frontiers in Physiology, Vol 12 (2021), Frontiers in Physiology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Diabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigenetic modifications usually regulate gene expression via DNA methylation, histone modification, and non-coding RNAs without altering the DNA sequence. During the past years, numerous studies have been published to reveal the mechanisms of epigenetic modifications that regulate inflammation in DN. This review aimed to summarize the latest evidence on the interplay of epigenetics and inflammation in DN, and highlight the potential targets for treatment and diagnosis of DN.
- Subjects :
- 0301 basic medicine
Chemokine
Physiology
Inflammation
Review
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Immune system
Physiology (medical)
Gene expression
medicine
QP1-981
Epigenetics
DNA methylation
biology
epigenetics
histone modifications
diabetic nephropathy
030104 developmental biology
Histone
inflammation
030220 oncology & carcinogenesis
biology.protein
Cancer research
non-coding RNAs
medicine.symptom
Subjects
Details
- Language :
- English
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Physiology
- Accession number :
- edsair.doi.dedup.....a404f08b2ffde0000962a0ab9b5fae13