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TNF-α-induced programmed cell death in the pathogenesis of acquired aplastic anemia
- Source :
- Expert review of hematology. 8(4)
- Publication Year :
- 2015
-
Abstract
- The mechanism of acquired aplastic anemia (AA), a bone marrow hematopoiesis failure disease, has not been fully understood. TNF-α is a pleiotropic cytokine involved in cell proliferation, differentiation and death, and inflammation through binding to specific receptors on cell membranes. Aberrant secretion of TNF-α contributes to a number of human diseases, including tumor development and inflammation. TNF-α is also an important negative regulator of hematopoiesis. Over-expression of TNF-α not only directly inhibits the proliferation and differentiation of hematopoietic cells, but also initiates the intracellular death pathway to induce hematopoietic cell death, leading to bone marrow hematopoiesis failure. In this review, we summarize the mechanisms underlying extrinsic apoptosis and necroptosis of hematopoietic cells induced by TNF-α, and discuss the role of TNF-α-induced programmed cell death in the pathogenesis of acquired AA.
- Subjects :
- Programmed cell death
business.industry
Tumor Necrosis Factor-alpha
Necroptosis
medicine.medical_treatment
Cell
Anemia, Aplastic
Inflammation
Apoptosis
Hematology
Receptors, Tumor Necrosis Factor
Hematopoiesis
Haematopoiesis
medicine.anatomical_structure
Cytokine
Immunology
Medicine
Animals
Humans
Bone marrow
medicine.symptom
business
Intracellular
Subjects
Details
- ISSN :
- 17474094
- Volume :
- 8
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Expert review of hematology
- Accession number :
- edsair.doi.dedup.....a40e82b560aa21282c7c3b903a3f653c