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Effect of prostaglandin E1 on preservation injury of canine liver grafts preserved in UW solution
- Source :
- Transplant International. 6:245-250
- Publication Year :
- 1993
- Publisher :
- Frontiers Media SA, 1993.
-
Abstract
- This study investigated whether prostaglandin E1 (PGE1) could reduce hepatic injury to the liver graft caused by harvesting and 24-h preservation in University of Wisconsin (UW) solution in a canine model. The PGE1-treated group was intravenously administered 0.5 microgram/kg per minute of PGE1 for 30 min before harvesting, as well as a concentration of 1 mg/l PGE1 in the washout and UW solutions. In both the PGE1-treated and the control group, all recipients survived for 1 week or more after transplantation. Arterial ketone body ratio (AKBR) remained over 1.0 in the early postoperative period. The PGE1 group showed significant reductions in guanase, GOT, and LDH during the early postoperative period compared to the untreated control group. Histological examination disclosed partial mitochondrial swelling, hepatocyte vacuolation, and necrosis in the control group, while such abnormalities were rarely seen in the PGE1 group. These results suggest that PGE1 can effectively reduce hepatic injury to liver grafts preserved in UW solution prior to transplantation.
- Subjects :
- medicine.medical_specialty
Adenosine
Time Factors
Necrosis
Allopurinol
Organ Preservation Solutions
Ischemia
Ketone Bodies
chemistry.chemical_compound
Dogs
Raffinose
medicine
Animals
Insulin
Viaspan
Aspartate Aminotransferases
Alprostadil
Prostaglandin E1
Liver preservation
Guanine Deaminase
Transplantation
L-Lactate Dehydrogenase
biology
business.industry
Fissipedia
Organ Preservation
respiratory system
medicine.disease
biology.organism_classification
Glutathione
Liver Transplantation
Surgery
Liver
chemistry
Reperfusion Injury
Anesthesia
Ketone bodies
lipids (amino acids, peptides, and proteins)
medicine.symptom
business
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 14322277 and 09340874
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Transplant International
- Accession number :
- edsair.doi.dedup.....a4103c11bf3362bdd707283b2eae80b5