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Gallium-Based Liquid Metal Particles for Therapeutics
- Source :
- Trends in Biotechnology. 39:624-640
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Gallium (Ga) and Ga-based liquid metal (LM) alloys offer low toxicity, excellent electrical and thermal conductivities, and fluidity at or near room temperature. Ga-based LM particles (LMPs) synthesized from these LMs exhibit both fluidic and metallic properties and are suitable for versatile functionalization in therapeutics. Functionalized Ga-based LMPs can be actuated using physical or chemical stimuli for drug delivery, cancer treatment, bioimaging, and biosensing. However, many of the fundamentals of their unique characteristics for therapeutics remain underexplored. We present the most recent advances in Ga-based LMPs in therapeutics based on the underlying mechanisms of their design and implementation. We also highlight some future biotechnological opportunities for Ga-based LMPs based on their extraordinary advantages.
- Subjects :
- 0301 basic medicine
Liquid metal
Materials science
Low toxicity
chemistry.chemical_element
Gallium
Bioengineering
Nanotechnology
02 engineering and technology
021001 nanoscience & nanotechnology
Cancer treatment
03 medical and health sciences
Drug Delivery Systems
030104 developmental biology
chemistry
Drug delivery
Alloys
Surface modification
Fluidics
0210 nano-technology
Biosensor
Biotechnology
Subjects
Details
- ISSN :
- 01677799
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Trends in Biotechnology
- Accession number :
- edsair.doi.dedup.....a455374175169af313d255759b173134