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Histone Deacetylase Inhibitors from Marine Invertebrates

Histone Deacetylase Inhibitors from Marine Invertebrates

Authors :
Claudio Luparello
Manuela Mauro
Vincenzo Arizza
Mirella Vazzana
Luparello, Claudio
Mauro, Manuela
Arizza, Vincenzo
Vazzana, Mirella
Source :
Biology, Vol 9, Iss 429, p 429 (2020), Biology
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Simple Summary Histone deacetylases (HDACs) are enzymes that control gene expression and are involved in the onset of serious human pathologies, including cancer; hence, their inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of molecules showing active pharmacological properties and an extensive spectrum of biomedical applications. This review is focused on the description of the molecular, biochemical, and, where available, physiological aspects of marine invertebrate-derived compounds that possess HDACi properties, taking into consideration their possible utilization as treatment agents against different pathological states. Abstract Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing many fundamental cellular processes. Due to the key involvement of HDACs in serious human pathologies, including cancer, HDAC inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of secondary metabolites showing active pharmacological properties and an extensive spectrum of biomedical applications. The aim of this review is to gather selected studies that report the extraction and identification of marine invertebrate-derived compounds that possess HDACi properties, grouping the producing species according to their taxonomic hierarchy. The molecular, biochemical, and/or physiological aspects, where available, and modes of action of these naturally occurring HDACis will be recapitulated, taking into consideration their possible utilization for the future design of analogs with increased bioavailability and efficacy, less toxicity, and, also, higher isoform selectivity.

Details

Language :
English
ISSN :
20797737
Volume :
9
Issue :
429
Database :
OpenAIRE
Journal :
Biology
Accession number :
edsair.doi.dedup.....a4a04c4db64e8ebfd3184de4d1e5b27b