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Histone Deacetylase Inhibitors from Marine Invertebrates
Histone Deacetylase Inhibitors from Marine Invertebrates
- Source :
- Biology, Vol 9, Iss 429, p 429 (2020), Biology
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Simple Summary Histone deacetylases (HDACs) are enzymes that control gene expression and are involved in the onset of serious human pathologies, including cancer; hence, their inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of molecules showing active pharmacological properties and an extensive spectrum of biomedical applications. This review is focused on the description of the molecular, biochemical, and, where available, physiological aspects of marine invertebrate-derived compounds that possess HDACi properties, taking into consideration their possible utilization as treatment agents against different pathological states. Abstract Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing many fundamental cellular processes. Due to the key involvement of HDACs in serious human pathologies, including cancer, HDAC inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of secondary metabolites showing active pharmacological properties and an extensive spectrum of biomedical applications. The aim of this review is to gather selected studies that report the extraction and identification of marine invertebrate-derived compounds that possess HDACi properties, grouping the producing species according to their taxonomic hierarchy. The molecular, biochemical, and/or physiological aspects, where available, and modes of action of these naturally occurring HDACis will be recapitulated, taking into consideration their possible utilization for the future design of analogs with increased bioavailability and efficacy, less toxicity, and, also, higher isoform selectivity.
- Subjects :
- 0301 basic medicine
Gene isoform
biomedical applications
marine invertebrates
Settore BIO/05 - Zoologia
Computational biology
Review
histone deacetylase inhibitors
General Biochemistry, Genetics and Molecular Biology
Chromatin remodeling
anticancer compound
03 medical and health sciences
Cnidaria
0302 clinical medicine
Non-histone protein
marine invertebrate
Gene expression
Epigenetics
Settore BIO/06 - Anatomia Comparata E Citologia
histone deacetylase inhibitor
lcsh:QH301-705.5
General Immunology and Microbiology
biology
Marine invertebrates
anticancer compounds
Porifera
030104 developmental biology
Histone
lcsh:Biology (General)
030220 oncology & carcinogenesis
biology.protein
biomedical application
Histone deacetylase
General Agricultural and Biological Sciences
Echinodermata
Subjects
Details
- Language :
- English
- ISSN :
- 20797737
- Volume :
- 9
- Issue :
- 429
- Database :
- OpenAIRE
- Journal :
- Biology
- Accession number :
- edsair.doi.dedup.....a4a04c4db64e8ebfd3184de4d1e5b27b