SAT-124 Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study (HAPO FUS): Newborn Anthropometrics and Childhood Glucose Metabolism

The prevalence of insulin resistance and type 2 diabetes (T2DM) in children is increasing, and identifying where prevention can best be implemented is an emerging area of research. The association of low birth weight with long-term risk for poor metabolic health is well established, but the association of newborn size at birth, including adiposity, with measures of glucose metabolism in children has not been fully elucidated. To address this, we used longitudinal data from the international, multi-ethnic Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and HAPO Follow Up Study (FUS). Newborn birth weight (BW) and sum of skinfolds (SSF), as a measure of adiposity, collected during HAPO, together with glucose and C-peptide levels collected during an oral glucose tolerance test (OGTT) in 4160 HAPO FUS offspring at age 10-14 years were examined. Multiple logistic and linear regression were used for statistical analyses to examine associations between primary predictors, BW and SSF, with child metabolic outcomes. Covariate adjustments included HAPO field center, child age, sex, Tanner stage, maternal variables at pregnancy OGTT (age, height, mean arterial pressure, parity (0, 1+), smoking (yes/no), drinking alcohol (yes/no), gestational age), child’s family history of diabetes in first degree relatives and child’s BMI z-score. BW was inversely associated with the 30-min, 1-h, and 2-h plasma glucose levels (Beta=-1.59, CI: -2.53 - -0.65, p