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Efficacy and safety of antagonists for chemoattractant receptor-homologous molecule expressed on Th2 cells in adult patients with asthma: a meta-analysis and systematic review
- Source :
- Respiratory Research, Respiratory Research, Vol 19, Iss 1, Pp 1-18 (2018)
- Publication Year :
- 2018
-
Abstract
- Background Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists are novel agents for asthma but with controversial efficacies in clinical trials. Therefore, we conducted a meta-analysis to determine the roles of CRTH2 antagonists in asthma. Methods We searched in major databases for RCTs comparing CRTH2 antagonists with placebo in asthma. Fixed- or random-effects model was performed to calculate mean differences (MD), risk ratio (RR) or risk difference (RD) and 95% confidence interval (CI). Results A total of 14 trails with 4671 participants were included in our final analysis. Instead of add-on treatment of CRTH2 antagonists to corticosteroids, CRTH2 antagonist monotherapy significantly improved pre-bronchodilator FEV1 (MD = 0.09, 95% CI 0.04 to 0.15, P = 0.0005), FEV1% predicted (MD = 3.65, 95% CI 1.15 to 6.14, P = 0.004), and AQLQ (MD = 0.25, 95% CI 0.09 to 0.41, P = 0.002), and reduced asthma exacerbations (RR = 0.45, 95% CI 0.23 to 0.85, P = 0.01). Rescue use of SABA was significantly decreased in both CRTH2 antagonist monotherapy (MD = − 0.04, 95% CI -0.05 to − 0.03, P
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Receptors, Prostaglandin
Review
Placebo
03 medical and health sciences
0302 clinical medicine
Th2 Cells
Internal medicine
medicine
Humans
Anti-Asthmatic Agents
Receptors, Immunologic
Adverse effect
Asthma
Randomized Controlled Trials as Topic
lcsh:RC705-779
business.industry
Absolute risk reduction
lcsh:Diseases of the respiratory system
medicine.disease
Confidence interval
Lung function
Clinical trial
Meta-analysis
030104 developmental biology
Treatment Outcome
030228 respiratory system
Relative risk
Adverse events
Systematic review
business
CRTH2 antagonist
Subjects
Details
- ISSN :
- 1465993X
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Respiratory research
- Accession number :
- edsair.doi.dedup.....a4b12b7e9037fd0e491423102fa07a75