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Test-based de-isolation in COVID-19 immunocompromised patients: Cycle threshold value versus SARS-CoV-2 viral culture
- Source :
- International Journal of Infectious Diseases, International Journal of Infectious Diseases, Vol 108, Iss, Pp 112-115 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background: Immunocompromised patients with coronavirus disease 2019 (COVID-19) have prolonged infectious viral shedding for more than 20 days. A test-based approach is suggested for de-isolation of these patients. Methods: The strategy was evaluated by comparing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load (cycle threshold (Ct) values) and viral culture at the time of hospital discharge in a series of 13 COVID-19 patients: six immunocompetent and seven immunocompromised (five solid organ transplant patients, one lymphoma patient, and one hepatocellular carcinoma patient). Results: Three of the 13 (23%) patients had positive viral cultures: one patient with lymphoma (on day 16) and two immunocompetent patients (on day 7 and day 11). Eighty percent of the patients had negative viral cultures and had a mean Ct value of 20.5. None of the solid organ transplant recipients had positive viral cultures. Conclusions: The mean Ct value for negative viral cultures was 20.5 in this case series of immunocompromised patients. Unlike those with hematological malignancies, none of the solid organ transplant patients had positive viral cultures. Adopting the test-based approach for all immunocompromised patients may lead to prolonged quarantine. Large-scale studies in disease-specific populations are needed to determine whether a test-based approach versus a symptom-based approach or a combination is applicable for the de-isolation of various immunocompromised patients.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Isolation (health care)
Short Communication
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
030106 microbiology
Infectious and parasitic diseases
RC109-216
Isolation
Immunocompromised Host
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
030212 general & internal medicine
Viral shedding
SARS-CoV-2
business.industry
Viral culture
COVID-19
General Medicine
medicine.disease
Virus Shedding
Lymphoma
Infectious Diseases
Hepatocellular carcinoma
Quarantine
Immunocompromised patients
business
Viral load
Subjects
Details
- ISSN :
- 12019712
- Volume :
- 108
- Database :
- OpenAIRE
- Journal :
- International Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....a4b54f7587acd43a130e9232ec82c438