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Phenolic compounds of Eugenia involucrata (Myrtaceae) extracts and associated antioxidant and inhibitory effects on acetylcholinesterase and α-glucosidase
- Source :
- Natural Product Research. 36:1134-1137
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Eugenia involucrata DC. (Myrtaceae), popularly known as “cereja-do-Rio-Grande”, is a native tree from Brazil, popularly used as a hypoglycemiant. Crude hydroalcoholic extract (CHE) and fractions (insoluble (FI), dichloromethane (FDM), ethyl acetate (FEA) and butanol (FBu)) of leaves were assessed to determine the phenolic chemical composition by HPLC-ESI-MS/MS. 10 compounds were identified, being 7 new for this species: rutin, isoquercitrin, luteolin-7-O-rutinoside, mandelic acid, naringenin, luteolin-7-O-glucoside and salicylic acid. Extract and fractions showed inhibitory activity on acetylcholinesterase (AchE) enzyme (best result: IC50 = 44.19 µg mL−1, for FEA) and α-glucosidase (α-Glu) (best result: IC50 = 31.25 ± 0.15 µg mL−1, for CHE). The observed antioxidant and inhibitory activity on the AchE and α-Glu is due to, at least in part, the presence of phenolic compounds in the samples.
- Subjects :
- Antioxidant
biology
Traditional medicine
010405 organic chemistry
α glucosidase
medicine.medical_treatment
Organic Chemistry
Myrtaceae
Plant Science
biology.organism_classification
Inhibitory postsynaptic potential
01 natural sciences
Biochemistry
Acetylcholinesterase
0104 chemical sciences
Analytical Chemistry
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
chemistry
Alpha-glucosidase
biology.protein
medicine
Subjects
Details
- ISSN :
- 14786427 and 14786419
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Natural Product Research
- Accession number :
- edsair.doi.dedup.....a4b634e1d489d92a5afe1d1c7e878fe3
- Full Text :
- https://doi.org/10.1080/14786419.2020.1855640