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Phenolic compounds of Eugenia involucrata (Myrtaceae) extracts and associated antioxidant and inhibitory effects on acetylcholinesterase and α-glucosidase

Authors :
Michele Debiasi Alberton
Andreza Cipriani
Adrielli Tenfen
Adrieli Luz de Sousa
André Luís de Gasper
Diogo Alexandre Siebert
Gustavo Amadeu Micke
Luciano Vitali
Source :
Natural Product Research. 36:1134-1137
Publication Year :
2020
Publisher :
Informa UK Limited, 2020.

Abstract

Eugenia involucrata DC. (Myrtaceae), popularly known as “cereja-do-Rio-Grande”, is a native tree from Brazil, popularly used as a hypoglycemiant. Crude hydroalcoholic extract (CHE) and fractions (insoluble (FI), dichloromethane (FDM), ethyl acetate (FEA) and butanol (FBu)) of leaves were assessed to determine the phenolic chemical composition by HPLC-ESI-MS/MS. 10 compounds were identified, being 7 new for this species: rutin, isoquercitrin, luteolin-7-O-rutinoside, mandelic acid, naringenin, luteolin-7-O-glucoside and salicylic acid. Extract and fractions showed inhibitory activity on acetylcholinesterase (AchE) enzyme (best result: IC50 = 44.19 µg mL−1, for FEA) and α-glucosidase (α-Glu) (best result: IC50 = 31.25 ± 0.15 µg mL−1, for CHE). The observed antioxidant and inhibitory activity on the AchE and α-Glu is due to, at least in part, the presence of phenolic compounds in the samples.

Details

ISSN :
14786427 and 14786419
Volume :
36
Database :
OpenAIRE
Journal :
Natural Product Research
Accession number :
edsair.doi.dedup.....a4b634e1d489d92a5afe1d1c7e878fe3
Full Text :
https://doi.org/10.1080/14786419.2020.1855640