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Decreased Cortical Folding of the Fusiform Gyrus and Its Hypoconnectivity with Sensorimotor Areas in Major Depressive Disorder
- Source :
- Journal of Affective Disorders. 295:657-664
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background : Neuroimaging studies have revealed abnormal cortical folding pattern and disruptive functional connectivity in major depressive disorder (MDD). Combining structure and function in the same population may further our understanding of the neuropathological mechanisms of MDD. Method : Sixty-two patients with MDD and 61 healthy controls (HCs) underwent structural and resting-state functional magnetic resonance imaging (MRI). Group differences in the cortical folding (measured by local gyrification index (LGI)) were analyzed in FreeSurfer. Taking the brain regions with significant group differences in LGI as seed regions, the resting-state functional connectivity analysis was further conducted to explore the corresponding functional connectivity alterations. Results : Comparing with HCs, patients with MDD showed significantly decreased LGI in the right fusiform gyrus (cohen's d = 0.70). In the seed-based functional connectivity analysis, we found that compared with HCs, patients with MDD showed decreased functional connections between the right fusiform gyrus with sensorimotor areas (precentral and postcentral gyrus) (cohen's d = 1.32) and right superior temporal gyrus (cohen's d = 0.94). Limitations : Main limitations are the relatively small sample size and the cross-sectional study design. Conclusion : Decreased LGI in the right fusiform gyrus, as well as decreased functional connectivity between the right fusiform gyrus and the sensorimotor area and right superior temporal gyrus, appears to play a role in the pathophysiology of MDD.
- Subjects :
- Population
behavioral disciplines and activities
Neuroimaging
mental disorders
medicine
Humans
education
Gyrification
Depressive Disorder, Major
education.field_of_study
Fusiform gyrus
medicine.diagnostic_test
business.industry
Postcentral gyrus
Brain
medicine.disease
Magnetic Resonance Imaging
Temporal Lobe
Sensorimotor Areas
Psychiatry and Mental health
Clinical Psychology
Cross-Sectional Studies
nervous system
Major depressive disorder
Sensorimotor Cortex
Functional magnetic resonance imaging
business
Neuroscience
Subjects
Details
- ISSN :
- 01650327
- Volume :
- 295
- Database :
- OpenAIRE
- Journal :
- Journal of Affective Disorders
- Accession number :
- edsair.doi.dedup.....a4bb47646b4bdbd8f55a704a63daedc5