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A self-destructive nanosweeper that captures and clears amyloid β-peptides
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018), Nature Communications
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Cerebral amyloid β-peptide (Aβ) accumulation resulting from an imbalance between Aβ production and clearance is one of the most important causes in the formation of Alzheimer’s disease (AD). In order to preserve the maintenance of Aβ homeostasis and have a notable AD therapy, achieving a method to clear up Aβ plaques becomes an emerging task. Herein, we describe a self-destructive nanosweeper based on multifunctional peptide-polymers that is capable of capturing and clearing Aβ for the effective treatment of AD. The nanosweeper recognize and bind Aβ via co-assembly through hydrogen bonding interactions. The Aβ-loaded nanosweeper enters cells and upregulates autophagy thus promoting the degradation of Aβ. As a result, the nanosweeper decreases the cytotoxicity of Aβ and rescues memory deficits of AD transgenic mice. We believe that this resourceful and synergistic approach has valuable potential as an AD treatment strategy.<br />Cerebral amyloid β-peptide accumulation is a causative factor in Alzheimer’s Disease. Here the authors design a 'nanosweeper' that binds amyloid β-peptide and induces autophagy to clear the accumulated plagues.
- Subjects :
- Genetically modified mouse
Amyloid
Science
Transgene
General Physics and Astronomy
Mice, Transgenic
Plaque, Amyloid
02 engineering and technology
010402 general chemistry
01 natural sciences
General Biochemistry, Genetics and Molecular Biology
Article
Polyethylene Glycols
Alzheimer Disease
Cell Line, Tumor
mental disorders
medicine
Autophagy
Animals
Humans
Amino Acid Sequence
Cytotoxicity
Maze Learning
lcsh:Science
Chitosan
Multidisciplinary
Amyloid beta-Peptides
Chemistry
Brain
General Chemistry
021001 nanoscience & nanotechnology
medicine.disease
0104 chemical sciences
Cell biology
Mice, Inbred C57BL
Disease Models, Animal
Cell culture
Nanoparticles
Beclin-1
lcsh:Q
Alzheimer's disease
0210 nano-technology
Peptides
Homeostasis
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....a4cf50743aa93d3d85ae1cf62804f083