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MR signal-fat-fraction analysis and T2* weighted imaging measure BAT reliably on humans without cold exposure
- Source :
- Metabolism, 70, 23-30. W B SAUNDERS CO-ELSEVIER INC
- Publication Year :
- 2016
-
Abstract
- Objective. Brown adipose tissue (BAT) is compositionally distinct from white adipose tissue (WAT) in terms of triglyceride and water content. In adult humans, the most significant BAT depot is localized in the supraclavicular area. Our aim is to differentiate brown adipose tissue from white adipose tissue using fat T2* relaxation time mapping and signal-fat-fraction (SFF) analysis based on a commercially available modified 2-point-Dixon (mDixon) water fat separation method. We hypothesize that magnetic resonance (MR) imaging can reliably measure BAT regardless of the cold-induced metabolic activation, with BAT having a significantly higher water and iron content compared to WAT.Material and methods. The supraclavicular area of 13 volunteers was studied on 3 T PET-MRI scanner using T2* relaxation time and SFF mapping both during cold exposure and at ambient temperature; and F-18-FDG PET during cold exposure. Volumes of interest (VOIs) were defined semiautomatically in the supraclavicular fat depot, subcutaneous WAT and muscle.Results. The supraclavicular fat depot (assumed to contain BAT) had a significantly lower SFF and fat T2* relaxation time compared to subcutaneous WAT. Cold exposure did not significantly affect MR-based measurements. SFF and T2* values measured during cold exposure and at ambient temperature correlated inversely with the glucose uptake measured by 18F-FDG PET.Conclusions. Human BAT can be reliably and safely assessed using MRI without cold activation and PET-related radiation exposure. (C) 2017 Elsevier Inc. All rights reserved.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Depot
Endocrinology, Diabetes and Metabolism
Glucose uptake
Adipose Tissue, White
Iron
Cold exposure
CHILDREN
White adipose tissue
Brown adipose tissue
ADULT HUMANS
030218 nuclear medicine & medical imaging
03 medical and health sciences
chemistry.chemical_compound
AGE
0302 clinical medicine
Endocrinology
Adipose Tissue, Brown
Fluorodeoxyglucose F18
Internal medicine
medicine
Humans
Obesity
medicine.diagnostic_test
Triglyceride
BROWN ADIPOSE-TISSUE
business.industry
Water
Magnetic resonance imaging
Triglyceride content
ta3121
F-18-FDG positron emission tomography
INSULIN
Magnetic Resonance Imaging
ADIPOCYTES
Cold Temperature
030104 developmental biology
medicine.anatomical_structure
chemistry
Positron emission tomography
Positron-Emission Tomography
business
Nuclear medicine
Subjects
Details
- ISSN :
- 15328600 and 00260495
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Metabolism: clinical and experimental
- Accession number :
- edsair.doi.dedup.....a4d4b62b7a95088a1e7afd13cbdba8b8