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Design and synthesis of nano Cu/chitosan-starch bio-composite for the treatment of human thyroid carcinoma
- Source :
- Arabian Journal of Chemistry, Vol 15, Iss 1, Pp 103465-(2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- In this study we report the green synthesis of nontoxic and stable Cu nanoparticles (NP) using chitosan/starch hydrogel with reducing/capping ability without using any harsh reducing agents. Starch was used as a reducing agent for the synthesis of Cu NPs that was further stabilized by chitosan polymers. The in situ prepared Cu NPs/CS-Starch bio-composite were characterized by advanced physicochemical techniques like Fourier Transformed Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray spectroscopy (EDX), X-ray Diffraction (XRD), UV–Vis, TGA and Inductively Coupled Plasma-Optical Emission Spectroscopic (ICP-OES) study. It has been established that Cu NPs/CS-Starch bio-composite have a spherical shape with a mean diameter from 5 to 7 nm. Cell viability of Cu NPs/CS-Starch bio-composite was very low against common human thyroid carcinoma cell lines i.e. TPC1, BCPAP and FTC133 without any cytotoxicity on normal cell line. The best anti-human thyroid carcinoma effects of Cu NPs/CS-Starch bio-composite was observed against the TPC1 cell line. For investigating the antioxidant properties of Cu NPs/CS-Starch bio-composite, the DPPH assay was used in the presence of butylated hydroxytoluene as the positive control. Cu NPs/CS-Starch bio-composite inhibited half of the DPPH molecules in the concentration of 207 µg/mL. The antioxidant activity of Cu NPs/CS-Starch bio-composite is significantly related to its anti-human thyroid carcinoma potentials. Based on to the above findings, the Cu NPs/CS-Starch bio-composite could be administrated for the treatment of several types of human thyroid carcinoma in humans.
- Subjects :
- Starch
Reducing agent
DPPH
General Chemical Engineering
technology, industry, and agriculture
Infrared spectroscopy
Chitosan-starch
Human thyroid carcinoma
General Chemistry
Chitosan
Thyroid carcinoma
Chemistry
chemistry.chemical_compound
chemistry
Transmission electron microscopy
Butylated hydroxytoluene
Copper nanoparticles
Antioxidant
QD1-999
Nuclear chemistry
Subjects
Details
- ISSN :
- 18785352
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Arabian Journal of Chemistry
- Accession number :
- edsair.doi.dedup.....a4d51bcfaa1ea1b375e2c274da5be05d