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A Comparison of Cell Activation, Exhaustion, and Expression of HIV Coreceptors and Restriction Factors in HIV-1- and HIV-2-Infected Nonprogressors
- Source :
- AIDS Research and Human Retroviruses, AIDS Research and Human Retroviruses, Mary Ann Liebert, In press, ⟨10.1089/AID.2020.0084⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Human immunodeficiency viruses induce rare attenuated diseases due either to HIV-1 in the exceptional long-term nonprogressors (LTNPs) or to HIV-2 in West Africa. To better understand characteristics of these two disease types we performed a multiplex comparative analysis of cell activation, exhaustion, and expression of coreceptors and restriction factors in CD4 T cells susceptible to harbor those viruses. We analyzed by flow cytometry the expression of HLA-DR, PD1, CCR5, CXCR6, SAMHD1, Blimp-1, and TRIM5α on CD4 T cell subsets from 10 HIV-1
- Subjects :
- 0301 basic medicine
CD4-Positive T-Lymphocytes
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Ubiquitin-Protein Ligases
Immunology
Human immunodeficiency virus (HIV)
HIV Infections
Biology
medicine.disease_cause
West africa
HIV Long-Term Survivors
Antiviral Restriction Factors
Tripartite Motif Proteins
03 medical and health sciences
0302 clinical medicine
Virology
medicine
Humans
030212 general & internal medicine
ComputingMilieux_MISCELLANEOUS
virus diseases
3. Good health
030104 developmental biology
Infectious Diseases
HIV-2
HIV-1
[SDV.IMM]Life Sciences [q-bio]/Immunology
Cell activation
Subjects
Details
- Language :
- English
- ISSN :
- 08892229
- Database :
- OpenAIRE
- Journal :
- AIDS Research and Human Retroviruses, AIDS Research and Human Retroviruses, Mary Ann Liebert, In press, ⟨10.1089/AID.2020.0084⟩
- Accession number :
- edsair.doi.dedup.....a4d65ffe15c24962ed5f0b34fb2a9df6