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Low skeletal muscle mass is associated with liver fibrosis in individuals with type 2 diabetes and nonalcoholic fatty liver disease

Authors :
Bajarang Bahadur
Parjeet Kaur
Manish K. Singh
Narendra S. Choudhary
Jasjeet Singh Wasir
Sunil Kumar Mishra
Sakshi Gagneja
Mohammad Shafi Kuchay
Tarannum Bano
Randhir Sud
Harmandeep Kaur Gill
Anu Mathew
Source :
Journal of Gastroenterology and Hepatology. 36:3204-3211
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

BACKGROUND AND AIM Type 2 diabetes (T2D) and low skeletal muscle mass (SMM) are associated with increased risk of nonalcoholic fatty liver disease (NAFLD). However, data regarding the association between low SMM and NAFLD-related liver fibrosis in individuals with T2D are scarce. Therefore, we aimed to investigate the association between low SMM and liver fibrosis in individuals with T2D and NAFLD. METHODS Controlled attenuation parameter (CAP) of ≥ 248 dB/m was taken as cutoff suggesting NAFLD. Clinically relevant liver fibrosis and advanced liver fibrosis were defined as liver stiffness measurement (LSM) by transient elastography (TE) of ≥ 8.0 and ≥ 9.6 kPa, respectively. SMM was measured using dual energy X-ray absorptiometry (DEXA). Low SMM was defined as appendicular SMM index of

Details

ISSN :
14401746 and 08159319
Volume :
36
Database :
OpenAIRE
Journal :
Journal of Gastroenterology and Hepatology
Accession number :
edsair.doi.dedup.....a5030bb2bd2dfdd21a03e1c0c5272554