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Subgroups of chemotherapy patients with distinct morning and evening fatigue trajectories
- Source :
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, vol 24, iss 4
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- PurposePurposes of this study were to identify subgroups of patients with distinct trajectories for morning and evening fatigue, evaluate for differences in demographic and clinical characteristics among these subgroups, and compare and contrast the predictors of subgroup membership for morning and evening fatigue.MethodsOutpatients with breast, gastrointestinal, gynecological, or lung cancer (n = 582) completed questionnaires, a total of six times over two cycles of chemotherapy (CTX). Morning and evening fatigue severity were evaluated using the Lee Fatigue Scale. Latent profile analysis (LPA) was used to identify distinct subgroups.ResultsThree latent classes were identified for morning fatigue (i.e., low (31.8 %), high (51.4 %), and very high (16.8 %)) and for evening fatigue (i.e., moderate (20.0 %), high (21.8 %), and very high (58.2 %)). Most of the disease and treatment characteristics did not distinguish among the morning and evening fatigue classes. Compared to the low class, patients in the high and very high morning fatigue classes were younger, had a lower functional status, and higher level of comorbidity. Compared to the moderate class, patients in the very high evening fatigue class were younger, more likely to be female, had child care responsibilities, had a lower functional status, and a higher level of comorbidity.ConclusionLPA allows for the identification of risk factors for more severe fatigue. Since an overlap was not observed across the morning and evening fatigue classes and unique predictors for morning and evening fatigue were identified, these findings suggest that morning and evening fatigue may have distinct underlying mechanisms.
- Subjects :
- Adult
Male
Gerontology
medicine.medical_specialty
Evening
Morning fatigue
medicine.medical_treatment
Antineoplastic Agents
Medical and Health Sciences
Article
03 medical and health sciences
0302 clinical medicine
Evening fatigue
Risk Factors
Clinical Research
Surveys and Questionnaires
Latent class analysis
Internal medicine
medicine
Humans
Chemotherapy
Longitudinal Studies
Oncology & Carcinogenesis
030212 general & internal medicine
Circadian rhythm
Fatigue
Aged
Cancer
Morning
business.industry
Diurnal variations
Psychology and Cognitive Sciences
Latent profile analysis
Middle Aged
medicine.disease
Treatment characteristics
Comorbidity
Latent class model
Circadian Rhythm
Oncology
030220 oncology & carcinogenesis
Female
Functional status
business
Subjects
Details
- ISSN :
- 14337339 and 09414355
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Supportive Care in Cancer
- Accession number :
- edsair.doi.dedup.....a506eb3260d747b89db1b1b80cf3ae25