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Protective effect of endogenous hydrogen sulfide against oxidative stress in gastric ischemia-reperfusion injury
- Source :
- Experimental and Therapeutic Medicine
- Publication Year :
- 2012
- Publisher :
- Spandidos Publications, 2012.
-
Abstract
- Hydrogen sulfide (H(2)S) is a gaseous signaling molecule, which plays a critical role in a number of physiological and pathological progresses. In order to determine the effect of endogenous H(2)S on gastric ischemia-reperfusion (GI-R), we evaluated the gastric mucosal damage in rats intraperitoneally injected with DL-propargylglycine (PAG, 50 mg/kg/day) or L-cysteine (L-cys, 50 mg/kg/day) for 7 days before GI-R. GI-R injury was achieved by clamping the celiac artery for 30 min, followed by reperfusion for 60 min. Gastric mucosal damage was macroscopically assessed in the area of injury and deep damage was assessed by histopathological scoring. PAG increased the area of gastric mucosal injury and deep damage compared with that in untreated GI-R rats (P
- Subjects :
- Cancer Research
medicine.medical_specialty
Pathology
hydrogen sulfide
DL-propargylglycine
medicine.disease_cause
Superoxide dismutase
chemistry.chemical_compound
Immunology and Microbiology (miscellaneous)
Internal medicine
medicine
Gastric mucosa
oxidative stress
gastric ischemia-reperfusion injury
Xanthine oxidase
biology
business.industry
Superoxide
Articles
General Medicine
Glutathione
Malondialdehyde
medicine.disease
Endocrinology
medicine.anatomical_structure
chemistry
biology.protein
business
Reperfusion injury
Oxidative stress
Subjects
Details
- ISSN :
- 17921015 and 17920981
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Experimental and Therapeutic Medicine
- Accession number :
- edsair.doi.dedup.....a50810924e1f1bb3ed285a9511f33990