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Orexin stimulates breathing via medullary and spinal pathways

Orexin stimulates breathing via medullary and spinal pathways

Authors :
Mingfei Wu
Joanne S. Allard
John Young
Serdia O Mack
Kebreten F. Manaye
Prabha Kc
Musa A. Haxhiu
Source :
Journal of Applied Physiology. 98:1387-1395
Publication Year :
2005
Publisher :
American Physiological Society, 2005.

Abstract

A central neuronal network that regulates respiration may include hypothalamic neurons that produce orexin, a peptide that influences sleep and arousal. In these experiments, we investigated 1) projections of orexin-containing neurons to the pre-Bötzinger region of the rostral ventrolateral medulla that regulates rhythmic breathing and to phrenic motoneurons that innervate the diaphragm; 2) the presence of orexin A receptors in the pre-Bötzinger region and in phrenic motoneurons; and 3) physiological effects of orexin administered into the pre-Bötzinger region and phrenic nuclei at the C3–C4 levels. We found orexin-containing fibers within the pre-Bötzinger complex. However, only 0.5% of orexin-containing neurons projected to the pre-Bötzinger region, whereas 2.9% of orexin-containing neurons innervated the phrenic nucleus. Neurons of the pre-Bötzinger region and phrenic nucleus stained for orexin receptors, and activation of orexin receptors by microperfusion of orexin in either site produced a dose-dependent, significant ( P < 0.05) increase in diaphragm electromyographic activity. These data indicate that orexin regulates respiratory activity and may have a role in the pathophysiology of sleep-related respiratory disorders.

Details

ISSN :
15221601 and 87507587
Volume :
98
Database :
OpenAIRE
Journal :
Journal of Applied Physiology
Accession number :
edsair.doi.dedup.....a509fba468970e6982cdca26e430a50c
Full Text :
https://doi.org/10.1152/japplphysiol.00914.2004