Catalytic Cyclopropanation of Alkenes Using Diazo Compounds Generated in Situ. A Novel Route to 2-Arylcyclopropylamines

Authors :: Roger V. Bonnert
Varinder K. Aggarwal
de Vicente J
Source :: Organic Letters. 3:2785-2788
Publication Year :: 2001
Publisher :: American Chemical Society (ACS), 2001.
Abstract: [reaction: see text]. A user-friendly, one-pot process for catalytic cyclopropanation of alkenes from tosylhydrazones is described. The cyclopropanation of N-vinylphthalimide provides a new route to 2-arylcyclopropylamines, and this is exemplified in the efficient synthesis of the HIV-1 reverse transcriptase inhibitor 6.

Subjects :: In situ
chemistry.chemical_compound
chemistry
Cyclopropanation
Organic Chemistry
Organic chemistry
Diazo
Physical and Theoretical Chemistry
Biochemistry
Catalysis

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