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Dietary supplement use is not associated with recurrence of colorectal adenomas: a prospective cohort study
- Source :
- International Journal of Cancer, 132, 666-75, International Journal of Cancer, 132(3), 666-675, Heine-Broring, R C, Winkels, R M, Botma, A, Wahab, PJ, Tan, A C I T, Nagengast, F M, Witteman, B J M & Kampman, E 2013, ' Dietary supplement use is not associated with recurrence of colorectal adenomas: A prospective cohort study ', International Journal of Cancer, vol. 132, no. 3, pp. 666-675 . https://doi.org/10.1002/ijc.27647, International Journal of Cancer, 132, 3, pp. 666-75, International Journal of Cancer 132 (2013) 3, International Journal of Cancer, 132(3), 666-675. International Union Against Cancer
- Publication Year :
- 2013
-
Abstract
- Diet and lifestyle influence colorectal adenoma recurrence. The role of dietary supplement use in colorectal adenoma recurrence remains controversial. In this prospective cohort study, we examined the association between dietary supplement use, total colorectal adenoma recurrence and advanced adenoma recurrence. Colorectal adenoma cases (n = 565) from a former case-control study, recruited between 1995 and 2002, were prospectively followed until 2008. Adenomas with a diameter of ≥1 cm and/or (tubulo)villous histology and/or with high grade dysplasia and/or ≥3 adenomas detected at the same colonic examination were considered advanced adenomas. Hazard ratios (HRs) and 95% confidence intervals (CIs) for dietary supplement users (use of any supplement during the past year) compared to nonusers and colorectal adenoma recurrence were calculated using stratified Cox proportional hazard models for counting processes and were adjusted for age, sex, educational level and number of colonoscopies during follow-up. Robust sandwich covariance estimation was used to adjust for the within subject correlation. A number of 165 out of 565 adenoma patients had at least one colorectal adenoma recurrence during a median person-time of 5.4 years and of these, 37 patients had at least one advanced adenoma. One-third of the total study population (n = 203) used a dietary supplement. Compared to no use, dietary supplement use was neither statistically significantly associated with total colorectal adenoma recurrence (HR = 1.03; 95% CI 0.79-1.34) nor with recurrent advanced adenomas (HR = 1.59; 95% CI 0.88-2.87). This prospective cohort study did not suggest an association between dietary supplement use and colorectal adenoma recurrence. What's new? People take vitamins and other dietary supplements for many reasons, but could your supplements be harmful? Heine-Bröring et al. investigated the effects of dietary supplements on colorectal adenomas, to better advise those at risk. Colorectal cancer is one of the most common types of cancer in the Western world, and one red flag for clinicians is the presence of colorectal adenomas. Patients who develop these asymptomatic growths have an increased risk of colorectal cancer. As more and more people have begun taking multivitamin supplements, it is important to know how to advise patients with recurrent colorectal adenomas regarding dietary supplements. The researchers conducted a cohort study, including 203 dietary supplement users and 362 nonusers, and looked at the relative frequency of colorectal adenomas in each group. Their results showed that taking dietary supplements such as vitamin C, calcium, or multivitamins did not reduce or increase a person's risk of colorectal adenoma recurrence. Use of B-vitamin supplements, however, were associated with an increase in total recurrent colorectal adenomas, but not with recurrent adenomas that showed advanced pathology. © 2012 UICC.
- Subjects :
- Male
Cancer Research
Nutrition and Disease
endocrine system diseases
food frequency questionnaire
Colonoscopy
cancer risk
Gastroenterology
clinical-trial
Cohort Studies
Voeding en Ziekte
Medicine
folic-acid
Prospective Studies
Prospective cohort study
Early Detection of Cancer
medicine.diagnostic_test
Hazard ratio
Middle Aged
health interview survey
Oncology
Population study
Female
Colorectal Neoplasms
Cohort study
Adenoma
medicine.medical_specialty
antioxidant vitamins
life-style
vitamin-d
united-states
Colorectal adenoma
SDG 3 - Good Health and Well-being
Translational research [ONCOL 3]
Internal medicine
Humans
Proportional Hazards Models
Molecular epidemiology Aetiology, screening and detection [NCEBP 1]
VLAG
business.industry
Proportional hazards model
Feeding Behavior
medicine.disease
relative validity
digestive system diseases
Diet
Surgery
stomatognathic diseases
Dietary Supplements
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 00207136
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer, 132, 666-75, International Journal of Cancer, 132(3), 666-675, Heine-Broring, R C, Winkels, R M, Botma, A, Wahab, PJ, Tan, A C I T, Nagengast, F M, Witteman, B J M & Kampman, E 2013, ' Dietary supplement use is not associated with recurrence of colorectal adenomas: A prospective cohort study ', International Journal of Cancer, vol. 132, no. 3, pp. 666-675 . https://doi.org/10.1002/ijc.27647, International Journal of Cancer, 132, 3, pp. 666-75, International Journal of Cancer 132 (2013) 3, International Journal of Cancer, 132(3), 666-675. International Union Against Cancer
- Accession number :
- edsair.doi.dedup.....a517765ce7e9d0d73fc50224a4f1a0c2