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Strong expression of polypeptide N-acetylgalactosaminyltransferase 3 independently predicts shortened disease-free survival in patients with early stage oral squamous cell carcinoma
- Source :
- Tumour Biology
- Publication Year :
- 2015
- Publisher :
- Springer Netherlands, 2015.
-
Abstract
- The polypeptide N-acetylgalactosaminyltransferase (GalNAc-Ts) family of enzymes regulates the critical initial steps of mucin-type O-glycosylation. Among GalNAc-Ts that may significantly influence cancer biology, thus affecting cell differentiation, adhesion, invasion, and/or metastasis, GalNAc-T3 exhibits a high expression in several human cancers, closely associated with tumor progression and a poor prognosis. However, the expression pattern of GalNAc-T3 in oral squamous cell carcinoma (OSCC) remains obscure. Since postoperative recurrence of even early stage OSCC (ESOSCC) occurs at an early phase, significantly affecting their clinical course and worse outcome, the identification of clinically significant accurate biomarkers is needed. Therefore, we investigated the correlation between the immunohistochemical GalNAc-T3 expression and various clinicopathological characteristics and recurrence using 110 paraffin-embedded tumor samples obtained from patients with surgically resected ESOSCC (T1–2N0). Recurrence was recognized in 37 of 110 (33.6 %) patients. The GalNAc-T3 expression was considered to be strongly positive when 20 % or more of the cancer cells showed positive cytoplasmic staining. Consequently, a strong expression of GalNAc-T3 was observed in 40 patients (36.4 %), showing a close relationship to poor differentiation, the presence of lymphatic and vascular invasion, and recurrence. Univariate and multivariate analyses further demonstrated that the patients with a strong GalNAc-T3+ status had markedly lower disease-free survival (DFS) rates, especially within the first 2 years postoperatively. Therefore, GalNAc-T3 might play a role in the pathogenesis of ESOSCC recurrence, and its immunohistochemical detection potentially predicts a shorter DFS and may be a useful parameter for providing clinical management against ESOSCC in the early postoperative phase. Electronic supplementary material The online version of this article (doi:10.1007/s13277-015-3928-7) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
Oncology
Cytoplasm
Cancer Research
Pathology
Glycosylation
Metastasis
Pathogenesis
Neoplasm Metastasis
Stage (cooking)
Aged, 80 and over
Mouth neoplasm
Cell Differentiation
General Medicine
Middle Aged
Disease-free survival (DFS)
Prognosis
Immunohistochemistry
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
Lymphatic system
Carcinoma, Squamous Cell
Disease Progression
N-Acetylgalactosaminyltransferases
Female
Mouth Neoplasms
Original Article
Erratum
Adult
medicine.medical_specialty
Biology
Polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
Disease-Free Survival
Young Adult
Cell Line, Tumor
Internal medicine
Biomarkers, Tumor
Cell Adhesion
medicine
Humans
Neoplasm Invasiveness
Aged
Vessel invasion
Gene Expression Profiling
Early stage OSCC (ESOSCC)
medicine.disease
Oral squamous cell carcinoma (OSCC)
carbohydrates (lipids)
Microscopy, Fluorescence
Tumor progression
Cancer cell
Neoplasm Recurrence, Local
Subjects
Details
- Language :
- English
- ISSN :
- 14230380 and 10104283
- Volume :
- 37
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Tumour Biology
- Accession number :
- edsair.doi.dedup.....a553895e56c2e7f718ab777fa1f5cfcc