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Effect of cephalic glucose infusion on insulin secretion
- Source :
- Diabetologia. 11:175-180
- Publication Year :
- 1975
- Publisher :
- Springer Science and Business Media LLC, 1975.
-
Abstract
- The continuous infusion of glucose (1 mg/kg/min) via the carotid artery in anesthetized dogs produces a biphasic pattern of insulin secretion. The first peak reaches a maximum 3 min after glucose infusion and drops to basal level at 7 min. As long as the glucose infusion persists a slow and mantained increase in insulin level in the pancreaticoduodenal vein can be observed. The same amount of glucose infused in the general circulation via the jugular vein provoked a different pattern of insulin secretion. Cerebral glucose infusion to vagotomized dogs also produced a two phase response to insulin secretion, but the levels reached in the first phase were lower that those observed in the normal dogs. The infusion of glucose, via the jugular vein, in vagotomized dogs, failed to induce any change in plasma insulin levels. Our data suggest that a glucose load to the brain induces pancreatic insulin secretion mediated partially by the vagus nerves. These results are also compatible with the hypothesis that a humoral factor could be involved in the pancreatic response.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Vagotomy
Dogs
Glucose infusion
Internal medicine
Jugular vein
Insulin Secretion
Internal Medicine
medicine
Animals
Insulin
Secretion
Insulin secretion
business.industry
Brain
Vagus Nerve
Carotid Arteries
Glucose
Endocrinology
Biphasic Pattern
Injections, Intra-Arterial
Basal (medicine)
General Circulation Model
Injections, Intravenous
Female
Jugular Veins
business
Subjects
Details
- ISSN :
- 14320428 and 0012186X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....a564ab98e7196cb7e31d27ab41809926
- Full Text :
- https://doi.org/10.1007/bf00422318