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The role and structure of mitochondrial carriers
- Source :
- FEBS Letters. (3):239-244
- Publisher :
- Federation of European Biochemical Societies. Published by Elsevier B.V.
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Abstract
- Members of the mitochondrial carrier family transport compounds over the inner mitochondrial membrane to link the biochemical pathways in the cytosol with those in the mitochondrial matrix. X-ray crystallography has recently provided us with the first atomic model of the bovine ADP/ATP carrier, which is a member of this family. The structure explains the typical three-fold sequence repeats and signature motif of mitochondrial carriers. However, the carrier was crystallised as a monomer in detergent, which is inconsistent with the consensus that mitochondrial carriers exist as homo-dimers. The projection structure of the yeast ADP/ATP carrier by electron crystallography shows that carriers could form homo-dimers in the membrane.
- Subjects :
- Models, Molecular
Mitochondrial carrier
Molecular Sequence Data
Biophysics
Biology
Biochemistry
Protein Structure, Secondary
Fungal Proteins
Protein structure
Structural Biology
Genetics
Animals
Humans
Amino Acid Sequence
Inner mitochondrial membrane
Molecular Biology
Peptide sequence
X-ray crystallography
Electron crystallography
Structure
Cell Biology
Mitochondria
Protein Structure, Tertiary
Cytosol
Membrane protein
Mitochondrial matrix
ATP–ADP translocase
Mitochondrial ADP, ATP Translocases
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....a5842dc11b692dc0837f5d49e7ecb06a
- Full Text :
- https://doi.org/10.1016/S0014-5793(04)00242-X